Peningkatan Laju Disolusi Furosemida Melalui Pembentukan Dispersi Padat dengan Polietilen Glikol (PEG), Talkum dan Kombinasi PEG-Talkum

Yandi Syukri

Abstract

Solid dispersions of furosemide were prepared by melting and solvent methods using polyethylene glycol (PEG) 6000, talc and PEG – talc as dispersion carrier in order to improve furosemide dissolution. The increase of dissolution and physical properties of its powder was evaluated. Only furosemide solid dispersions with combination of PEG – talc 1 : 3 showed a good physical properties. The assay of the effect of PEG – talc ratio on furosemide dissolution showed that the increase of ratio of PEG – talc increased significantly (p < 0,05) dissolution rate Infrared spectra analysis was seen the exist of the moving of the spectra and the changes of spectra profile that reint force the asumtion of the exist of the molecular interaction between furosemide and PEG 6000.

keyword : furosemide, solid dispersion, dissolution



Publisher:

PPST DPPM Universitas Islam Indonesia

ISSN: 1410-2315