RESVERATROL OLIGOMERS FROM DIPTEROCARPUS HASSELTII: CYTOTOXIC EFFECT AND CHEMOTAXONOMIC SIGNIFICANCE

Muhtadi Muhtadi, Euis H. Hakim, Yana M. Syah, Lia D. Juliawaty, Jalifah Latip

Abstract

ABSTRACT
Two resveratrol tetramers, (-)-vaticanol B and (-)-hopeaphenol, were isolated from acetone
extract of the tree bark of Dipterocarpus hasseltii (Dipterocarpaceae), together with the known
resveratrol trimer, (-)-α-viniferin. The structures of these compounds were established based on
spectroscopic evidence, UV, IR,
1
H-NMR,
13
C-NMR and determined by comparison with the
standard compounds. The cytotoxic activities of these compounds were evaluated against murine
leukaemia P-388 cells. The IC50 values of all compounds were 42.2, 5.0 and 17.5 μg/ml,
respectively. In addition, chemotaxonomic significance relationship between Dipterocarpus, Shorea
and Vatica will also be briefly discussed.

Keywords: Chemotaxonomy, Cytotoxic, Dipterocarpaceae, D. hasseltii,Resveratrol
tetramer

Full Text:

PDF

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM




Jurnal Ilmiah Farmasi (JIF) is currently indexed by:

    
     

Jurnal Ilmiah Farmasi (JIF)
Published by:
Department of Pharmacy, Faculty of Mathematics and Science,
Universitas Islam Indonesia.

Print ISSN 1693-8666, Online ISSN 2657-1420

Creative Commons License
JIF at  http://journal.uii.ac.id/JIF/ is licensed under a Creative Commons Attribution 4.0 International License.