RESVERATROL OLIGOMERS FROM DIPTEROCARPUS HASSELTII: CYTOTOXIC EFFECT AND CHEMOTAXONOMIC SIGNIFICANCE
Two resveratrol tetramers, (-)-vaticanol B and (-)-hopeaphenol, were isolated from acetone
extract of the tree bark of Dipterocarpus hasseltii (Dipterocarpaceae), together with the known
resveratrol trimer, (-)-Î±-viniferin. The structures of these compounds were established based on
spectroscopic evidence, UV, IR,
C-NMR and determined by comparison with the
standard compounds. The cytotoxic activities of these compounds were evaluated against murine
leukaemia P-388 cells. The IC50 values of all compounds were 42.2, 5.0 and 17.5 Î¼g/ml,
respectively. In addition, chemotaxonomic significance relationship between Dipterocarpus, Shorea
and Vatica will also be briefly discussed.
Keywords: Chemotaxonomy, Cytotoxic, Dipterocarpaceae, D. hasseltii,Resveratrol
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Jurnal Ilmiah Farmasi (JIF)
Department of Pharmacy, Faculty of Mathematics and Science,
Universitas Islam Indonesia.
Print ISSN 1693-8666, Online ISSN 2657-1420
JIF at http://journal.uii.ac.id/JIF/ is licensed under a Creative Commons Attribution 4.0 International License.