Profile of Medication Variations and Dose Adjustment to Diabetes Mellitus Patientsâ€™ Response in PKU Muhammadiyah Hospital dan Panti Rapih Hospital period October â€“ December 2014
Background: Diabetes mellitus patients may have a different response to similar medication. Therefore, individualized treatment and monitoring of the therapy is needed to ensure the patientsâ€™ response. Alternative medication or dose adjustment should be considered in order to achieve the therapeutic goal.
Objective: The aim of this study was to find out patientsâ€™ response to medication variation or dose adjustment .
Methods: This study used descriptive design in PKU Muhammadiyah Hospital and Panti Rapih Hospital period October-December 2014. Participants are all patients who got pharmacological therapy for treatment of diabetes mellitus type 2, including oral antidiabetics and/or insulinand met the inclusion criteria. The response of therapy was checked 2 times, during check-in and check-out.
Results: Analysis of response variation showed that individualized response existed, in which positive response occurred in 10 patients and the other had a negative response. The changes were dose adjustment and medication alteration or medication addition. From 6 patients who needed medication adjusment, 5 patients had a positive response, and others had a negative response. Whereas from 6 patients whose dosage or medication was not changed, 5 of them had a positive response while one had a negative response.
Conclusion: Individualized treatment is needed to achieve a therapeutic goal. Individualized treatment can be done through dose adjustment and medication alteration, or medications addition.