Profile of medication variations and dose adjustment to diabetes mellitus patients’ response in PKU Muhammadiyah hospital and Panti Rapih hospital period October–December 2014

Imaniar Noor Faridah, Dyah Aryani Perwitasari, Desty Kusumaningsih, Riana Prastiwi Handayani


Background: Diabetes mellitus patients may have a different response to
similar medication. Therefore, individualized treatment and monitoring
of the therapy is needed to ensure the patients’ response. Alternative
medication or dose adjustment should be considered in order to achieve
the therapeutic goal.
Objective: The aim of this study was to find out patients’ response to
medication variation or dose adjustment.
Methods: This study used descriptive design in PKU Muhammadiyah
Hospital and Panti Rapih hospital period October-December 2014.
Participants are all patients who got pharmacological therapy for treatment
of diabetes mellitus type 2, including oral antidiabetics and/ insulin and
met the inclusion criteria. The response of therapy was checked 2 times,
during check-in and check-out.
Results: Analysis of response variation showed that individualized
response existed, in which positive response occurred in 10 patients and
the other had a negative response. The changes were dose adjustment
and medication alteration or medication addition. From 6 patients who
needed medication adjusment, 5 patients had a positive response, and
others had a negative response. Whereas from 6 patients whose dosage or
medication was not changed, 5 of them had a positive response while one
had a negative response.
Conclusion: Individualized treatment is needed to achieve a therapeutic
goal. Individualized treatment can be done through dose adjustment and
medication alteration, or medications addition.


Medication response, hospital, diabetes mellitus

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