Validasi Metode Bioanalisis Vankomisin HCl dalam Spiked-plasma Manusia Menggunakan KCKT-UV untuk Aplikasi PKOD

Ari Wibowo, Damas Inggil Maulidina, Wahyuni Shalatan Fitri, Vitarani Ningrum

Abstract

As the first-line antibiotic for the treatment of infections caused by methicillin-resistant Staphylococcus aureus  (MRSA), vancomycin has  a narrow therapeutic index with high pharmacokinetic   variability. Therefore, it is deemed necessary to examine its concentration in the blood as a strategy to monitor the fulfillment of therapeutic levels  in patients receiving vancomycin. This study aimed to validate vancomycin bioanalysis  in  spiked-human  plasma  for  the  applications  of  therapeutic  drug  monitoring  (TDM).

Keywords

Vankomisin; Plasma; Validasi Metode; KCKT detektor UV; Aplikasi PKOD

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Eksakta: Jurnal Ilmu-Ilmu MIPA
Journal of Mathematics and Natural Sciences

ISSN 1411-1047 (print), ISSN 2503-2364 (online)
Published by: 
Faculty of Mathematics and Natural Sciences
Universitas Islam Indonesia, Yogyakarta

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