Synthesis of 4 Phenyl 3,4 Dihydr Indeno[2â€²,1â€²]Pyrimidine 2 One on Different Amount of Catalysts
pharmacologicÂ andÂ therapeuticÂ activities.Â ThisÂ compoundÂ canÂ beÂ synthesisedÂ byÂ using
BiginelliÂ reactionÂ whichÂ involveÂ threeÂ typeÂ ofÂ startingÂ materialsÂ andÂ alsoÂ haveÂ been
developedÂ intoÂ different methodÂ Â Â ofÂ reactionÂ conditionÂ andÂ starting material.Â LR1Â (4
phenyl3,4dihydroindeno[2â€²,1â€²]pyrimidine2one)Â isÂ aÂ derivativeÂ ofÂ dihydropirimidine.
This research was aimed to study the effect of catalyst amount in the synthesis of LR1 in
order to reach the optimal yield.Â
LR1 can be synthesised form benzaldehyde, urea adn 2indanone in ethanol and concentrated chloric acid as catalyst for five hours under reflux. The product mixture was thenÂ extractedÂ andÂ isolatedÂ byÂ columnÂ chromatographyÂ preparative.Â The meltingÂ point was checked to determine the purity of the product. The structure elucidation was carried out by using spectroscopic method (uvvis, IR, 1HNMR and MS) The result showed that the highest yield of LR1 was obtained around 15 % when 0.25 %Â of chloric acid used as catalyst. The higher the condition of acid in the reaction, the lower the tield of LR1 obtained.
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