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Abstract
Abstract
Background: Cancer has become a major cause of global health problems. Latest research currently focuses on an approach to cancer therapy that involves specific target molecules and theragnostic (therapy and diagnostic) agents. Among the specific target molecules in cancer therapy is LAT1, which is over expressed in cancer cells but under expressed in normal cells. Therefore, LAT1 inhibition can become an alternative to cancer therapy. A number of studies have shown that JPH203 specifically inhibits LAT1, thus reducing amino acid absorption into cancer cells and inhibiting cancer cell growth.
Objective: The main objective of this literature study was to determine the potential of JPH203 as a LAT1 inhibitor to be developed into a novel theragnostic agent for cancer.
Methods: Various studies were summarized to outline the development of JPH203 as a therapy targeting LAT1 and potential candidate of theragnostic compounds.
Results: The results of the literature study showed that JPH203 as a selective LAT1 inhibitor was able to efficiently suppress the growth of cancer cells with a low IC50 value.
Conclusion: The activity of LAT1 as an amino acid transporter of cancer cells could be selectively inhibited by JPH203, thereby allowing JPH203 to be reconsidered as a potential therapy in the development of theragnostic compounds against cancer.
Keywords: JPH203, theragnostic, LAT1 inhibitor
Intisari
Latar belakang: Kanker telah menjadi penyebab masalah kesehatan utama di dunia. Saat ini penelitian terbaru berfokus pada pendekatan terapi kanker yang melibatkan molekul target yang spesifik dan menggunakan senyawa teranostik (terapi dan diagnostik). Salah satu molekul target spesifik dalam terapi kanker adalah LAT1 yang terekspresi berlebih pada sel kanker, namun sedikit pada sel normal. Oleh karena itu, inhibisi LAT1 dapat menjadi alternatif terapi kanker. Beberapa penelitian menunjukkan inhibitor yang secara spesifik menghambat LAT1 adalah JPH203, sehingga penyerapan asam amino ke dalam sel kanker dapat berkurang dan menghambat pertumbuhan sel kanker.
Tujuan: Tujuan utama dari studi literatur ini adalah untuk mengetahui potensi JPH203 yang merupakan inhibitor LAT1 dalam perannya sebagai senyawa teranostik baru terhadap penyakit kanker.
Metode: Berbagai penelitian dirangkum mengenai pengembangan JPH203 sebagai terapi pentarget-LAT1 dan potensinya sebagai kandidat senyawa teranostik.
Hasil: Hasil studi literatur yang dilakukan menunjukkan bahwa JPH203 sebagai inhibitor selektif LAT1 mampu menekan pertumbuhan sel kanker secara efisien dengan didapatkan hasil IC50 yang rendah.
Kesimpulan: Aktivitas LAT1 sebagai transporter asam amino sel kanker dapat dihambat secara selektif oleh JPH203, sehingga dapat dipertimbangkan kembali sebagai target terapi potensial yang dapat digunakan dalam pengembangan senyawa teranostik kanker.
Kata kunci : JPH203, teranostik, inhibitor LAT1
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