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cover JIF 18(1) 2022
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August 8, 2021
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December 28, 2021
Published
July 21, 2022
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Abstract

Background: Flavonoids are widely employed as phytomedicines and as secondary metabolites generated by plants, where they serve key roles in plant physiology. Antioxidant, anti-inflammatory, anticancer, antibacterial, antifungal, and antiviral activities are only a few of the potential biological effects of flavonoids. The discovery of medicinal plants containing flavonoid chemicals is potential as a supportive and preventative treatment, notably for COVID-19 which has caused a pandemic in several countries, including Indonesia.
Objective: This study aimed to determine the total flavonoid content in the ethanolic extracts of C. asiatica leaves and Imperata cylindrica roots to find the potential of flavonoid-rich plants as an alternative source of COVID-19 treatment.
Methods: The ethanolic extracts from the combination of C. asiatica leaves and I. cylindrica roots (with five combination ratios) were tested for total flavonoid content using the UV-Vis Spectrophotometry method. The total flavonoid content of the extract combination was analyzed using a one-way ANOVA test.
Results: The total flavonoid contents of the combination of C. asiatica leaf and I. cylindrica root extracts at a ratio of 1:1, 2:3, 3:2, 4:1, and 1:4 were 45.88 ± 0.08, 42.14 ± 0.08, 40.52 ± 0.08, 66.28 ± 0.08, and 40.88 ± 0.13 mg/g EQ, respectively. The homogeneity with Levene's test obtained a p-value of 0.303. The one-way ANOVA exhibited the p-value of F-test statistics < 0.001.
Conclusion: The total flavonoid contents of ethanolic extracts from C. asiatica leaves and I. cylindrica roots are at a ratio of 4:1 > 1:1 > 2:3 > 1:4 > 3:2. The high total flavonoid content plays a role in increasing anti-inflammatory and immunomodulatory activities in COVID-19 patients.
Keywords: Total flavonoid content, C. asiatica, I. cylindrica, UV-Vis Spectrophotometry, COVID-19

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Author Biographies

Anita Puspa Widiyana, Department of Pharmacy, Faculty of Medicine, Universitas Islam Malang, Malang, Indonesia

Department of Pharmacy

Sri Herlina, Department of Medicine, Faculty of Medicine, Universitas Islam Malang, Malang, Indonesia

Department of Medicine

Didi Nurhadi Illian, Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia

Department of Pharmacy
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