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Abstract
ABSTRACT
Solid dispersions of the antiinflamation drug ibuprofen and polyethylene glycol 6000 (PEG
6000) were prepared by the melting method in order to increase the dissolution rates of this poorly
water-soluble compound. The temperature/composition phase diagram of binary system was
analyzed by termal analysis hot-stage microscopy, showing an eutectic formation. Polarized light
hot stage microscopy and X-ray-powder diffraction confirmed, that solid dispersion technique
decrease the crystalliny of ibuprofen after melting and solidifying of a 4/6 (w/w) mixture of ibuprofen
and polyethylene glycol 6000 respectively, which the results enhanced dissolution rates compared
to the physical mixtures and ibuprofen intact. However, no such chemical interactions in the solid
state were confirmed by FTIR spectra which showed the presence of ibuprofen crystalline in solid
dispersion.
Keywords: solid dispersions, ibuprofen, polyethylene glycol 6000
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