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Abstract
ABSTRACT
Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L.
(Melastomataceae) have been investigated. The n-hexane extract yielded -amyrin, patriscabatrine
and auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gave
quercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts and
isolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidant
assay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op-
trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition more
than 90% in the FTC method. Quercetin was found to be the most active as radical scavenger in
DPPH method with IC50 of 0.69 M. -Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl)
glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPA
mouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively.
Keywords: Antiinflammatory, Antioxidant, Flavonoids, Melastomataceae, Melastoma
malabathricum, Terpenoid