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Submitted
February 4, 2019
Accepted
April 30, 2019
Published
April 30, 2019
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Abstract

Garcinia dulcis is a medicinal plant used traditionally to treat various diseases including infections of wounds and ulcers. The antibacterial activity of this plant has also been widely reported, but the most potent compounds as an antibacterial agent are not widely reported, even though the compounds contained in this plant is well known. This paper reviews the compounds contained in G. dulcis plants and their potential as antibacterial agents. Each part of this plant, such as leaves, fruits, flowers, seeds, stems, and roots, contains secondary metabolites which are potential antibacterial agents. Here are described the compounds contained in each part of the plant, such as xanthones, the most dominant compounds, then flavonoids, benzophenones, chromones, and triterpenoid. Their antibacterial activity is also described, especially those that have strong activity against bacteria. The molecular structure and the possibilities of how the antibacterial mechanism are also discussed.  Eleven compounds that have the potential to be used as antibacterial agents for the treatment of infectious diseases. Garcigerin A (27) and a-mangostin (54) are compounds that have the most vigorous activity against S. aureus and MRSA compared to the other compounds. The Compounds that have strong activity can be used as antibacterial agents for anti-infective therapy, although they must go through various further studies.

Keywords

Garcinia dulcis antibacterial chemical compounds xanthones flavonoids benzophenone

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How to Cite
Tamhid, H. A. (2019). Chemical compounds and antibacterial activity of Garcinia dulcis (Roxb)kurz. JKKI : Jurnal Kedokteran Dan Kesehatan Indonesia, 10(1), 71–85. https://doi.org/10.20885/JKKI.Vol10.Iss1.art11
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References

  1. Savoia D. Plant-derived antimicrobial compounds: alternatives to antibiotics. Future Microbiol 2012; 7: 979–990.
  2. Newman DJ, Cragg GM. Natural Products as Sources of New Drugs over the 30 Years. J Nat Prod 2012; 75: 311–335.
  3. Radulovic NS, Blagojevic PD, Stojanovic-Radic ZZ, et al. Antimicrobial plant metabolites: structural diversity and mechanism of action. Curr Med Chem 2013; 20: 932–52.
  4. Djaja S, Suwandono A, Soemantri S. Pola penyakit penyebab kematian di perkotaan dan pedesaan di Indonesia , Studi Mortalitas Survei Kesehatan Rumah Tangga ( SKRT ) 2001. J Kedokt Trisakti 2003; 22: 37–46.
  5. Ventola CL. The antibiotic resistance crisis: part 1: causes and threats. Pharm Ther J 2015; 40: 277–83.
  6. Prescott TAK, Kiapranis R, MacIver SK. Comparative ethnobotany and in-the-field antibacterial testing of medicinal plants used by the Bulu and inland Kaulong of Papua New Guinea. J Ethnopharmacol 2012; 139: 497–503.
  7. Kasahara S, Henmi S. Medicine Herb Index in Indonesia. In: Eisai Indonesia. Jakarta, 1986, p. 92.
  8. Deachathai S, Mahabusarakam W, Phongpaichit S, et al. Phenolic compounds from the flowers of Garcinia dulcis. Phytochemistry 2006; 67: 464–469.
  9. Deachathai S, Phongpaichit S, Mahabusarakam W. Phenolic compounds from the seeds of Garcinia dulcis. Nat Prod Res 2008; 22: 1327–1332.
  10. Likhitwitayawuid K, Chanmahasathien W, Ruangrungsi N, et al. Xanthones with antimalarial activity from Garcinia dulcis. Planta Med 1998; 64: 281–282.
  11. Tuansulong K, Hutadilok-towatana N, Mahabusarakam W, et al. Morelloflavone from Garcinia dulcis as a Novel Biflavonoid Inhibitor of HMG-CoA Reductase. 2011; 428: 424–428.
  12. Deachathai S, Mahabusarakam W, Phongpaichit S, et al. Phenolic compounds from the fruit of Garcinia dulcis. Phytochemistry 2005; 66: 2368–2375.
  13. Tamhid HA, Wahyuono S, Hertiani T. Aktivitas Antibakteri Senyawa Isolat Daun Mundu (Garcinia dulcis) terhadap Bakteri Patogen. J Ilm Farm; 11.
  14. Abu Bakar MF, Ahmad NE, Suleiman M, et al. Garcinia dulcis Fruit Extract Induced Cytotoxicity and Apoptosis in HepG2 Liver Cancer Cell Line. Biomed Res Int; 2015. Epub ahead of print 2015. DOI: 10.1155/2015/916902.
  15. Setiawan A, Hanum L, Rusmiyanto E, et al. The Effect Of Mundu Fruit ( Garcinia dulcis ( Roxb .) Kurz ) Methanol Extract On Lyphoprotein Profile And Trygliseride White Rat ( Rattus norvegicus L ). J Biol Res 2014; 19: 74–77.
  16. Thongsepee N, Mahabusarakam W, Thong-asa W, et al. Vasorelaxant mechanisms of camboginol from Garcinia dulcis in normotensive and 2-kidneys-1-clip hypertensive rat. Songklanakarin J Sci Technol 2018; 40: 1248–1258.
  17. Utami N, Sari R. Mundu: Garcinia xanthocymus Hook.F. atau Garcinia dulcis (Roxb.)Kurz. Ber Biol 2009; 9: 739–744.
  18. Lim TK. Edible Medicinal and Non-Medicinal Plants. 2016. Epub ahead of print 2016. DOI: 10.1007/978-94-017-7276-1.
  19. Te-Chato S. Floral and fruit morphology of some species in Garcinia spp. Songklanakarin J Sci Technol 2007; 29: 245–252.
  20. Begum A, Barthakur SK, Sarma J. Garcinia dulcis ( Roxburgh ) Kurz [ Clusiaceae ]: a new distributional record for Assam , India. Pleione 2013; 7: 545–548.
  21. Matsumoto K, Yukihiro A, Emi K, et al. from Garcinia Species Display a Strong Apoptosis-Inducing Effect against. Biol PharmBull 2003; 26: 569–571.
  22. Nilar, Nguyen LHD, Venkatraman G, et al. Xanthones and benzophenones from Garcinia griffithii and Garcinia mangostana. Phytochemistry 2005; 66: 1718–1723.
  23. Baggett S, Protiva P, Mazzola EP, et al. Bioactive Benzophenones from Garcinia x anthochymus Fruits. J Nat Prod 2005; 68: 354–360.
  24. Padhye S, Ahmad A, Oswal N, et al. Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs. J Hematol Oncol 2009; 2: 1–13.
  25. Kolodziejczyk J, Masullo M, Olas B, et al. Effects of garcinol and guttiferone K isolated from Garcinia cambogia on oxidative/nitrative modifications in blood platelets and plasma. Platelets 2009; 20: 487–492.
  26. Iwashina T. The Structure and Distribution of the Flavonoids in Plants. J Plant Res 2000; 113: 287–299.
  27. Saelee A, Phongpaichit S, Mahabusarakam W. Natural Product Research?: Formerly Natural Product Letters A new prenylated biflavonoid from the leaves of Garcinia dulcis. Nat Prod Res Former Nat Prod Lett 2015; 37–41.
  28. Abdullah I, Phongpaichit S, Voravuthikunchai SP, et al. Prenylated biflavonoids from the green branches of Garcinia dulcis. Phytochem Lett 2018; 23: 176–179.
  29. Ansari WH, Rahman W, Barraclough D, et al. Biflavanoids and a Flavanone-Chromone from the Leaves of Garcinia dulcis(Roxb.) Kurz. J Chem Soc, Perkin Trans 1976; I: 1458–1463.
  30. Matos MJ, Vazquez-Rodriguez S, Uriarte E, et al. Synthesis and pharmacological activities of non-flavonoid chromones: a patent review (from 2005 to 2015). Expert Opin Ther Pat 2015; 25: 1285–1304.
  31. Chantarasriwong O, Batova A, Chavasiri W, et al. Chemistry and biology of the caged Garcinia xanthones. Chem - A Eur J 2010; 16: 9944–9962.
  32. Pedraza-Chaverri J, Cárdenas-Rodríguez N, Orozco-Ibarra M, et al. Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol 2008; 46: 3227–3239.
  33. Mahabusarakam W, Chairerk P, Taylor WC. Xanthones from Garcinia cowa Roxb. latex. Phytochemistry 2005; 66: 1148–1153.
  34. Negi JS, Bisht VK, Singh P, et al. Naturally Occurring Xanthones: Chemistry and Biology. J Appl Chem 2013; 2013: 1–9.
  35. Panda SS, Chand M, Sakhuja R, et al. Xanthones as Potential Antioxidants. Curr Med Chem 2013; 20: 4481–4507.
  36. Fouotsa H, Lannang AM, Dzoyem JP, et al. Antibacterial and antioxidant xanthones and benzophenone from garcinia smeathmannii. Planta Med 2015; 81: 594–599.
  37. Tantapakul C, Maneerat W, Sripisut T, et al. New Benzophenones and Xanthones from Cratoxylum sumatranum ssp. neriifolium and Their Antibacterial and Antioxidant Activities. J Agric Food Chem 2016; 64: 8755–8762.
  38. Mawa S, Said IM. Chemical constituents of Garcinia prainiana. Sains Malaysiana 2012; 41: 585–590.
  39. Baskar K, Duraipandiyan V, Ignacimuthu S. Bioefficacy of the triterpenoid friedelin against Helicoverpa armigera (Hub.) and Spodoptera litura (Fab.) (Lepidoptera: Noctuidae). Pest Manag Sci 2014; 70: 1877–1883.
  40. Quintans JSS, Costa E V., Tavares JF, et al. Phytochemical study and antinociceptive effect of the hexanic extract of leaves from Combretum duarteanum and friedelin, a triterpene isolated from the hexanic extract, in orofacial nociceptive protocols. Brazilian J Pharmacogn 2014; 24: 60–66.
  41. Harrison LJ, Leong L, Leong Y, et al. Xanthone and Flavonoid Constituents of Garcinia dulcis ( Guttiferae ). Nat Prod Lett 1994; 5: 111–116.
  42. Annan K, Adu F, Gbedema SY. Friedelin?: a Bacterial Resistance Modulator From Paullinia Pinnata L . Bact Resist Modul 2009; 29: 152–159.
  43. Sunil C, Duraipandiyan V, Ignacimuthu S, et al. Antioxidant, free radical scavenging and liver protective effects of friedelin isolated from Azima tetracantha Lam. leaves. Food Chem 2013; 139: 860–865.
  44. Duraipandiyan V, Al-Dhabi NA, Irudayaraj SS, et al. Hypolipidemic activity of friedelin isolated from Azima tetracantha in hyperlipidemic rats. Brazilian J Pharmacogn 2016; 26: 89–93.
  45. Antonisamy P, Duraipandiyan V, Ignacimuthu S, et al. Anti-diarrhoeal activity of friedelin isolated from Azima tetracantha Lam. in Wistar rats. South Indian J Biol Sci 2015; 1: 34–37.
  46. Iinuma M, Ito T, Tosa H, et al. Five New Xanthones from Garcinia dulcis. J Nat Prod 1996; 59: 472–475.
  47. Thepthong P, Phongpaichit S, Carroll AR, et al. Prenylated xanthones from the stem bark of Garcinia dulcis. Phytochem Lett 2017; 21: 32–37.
  48. Mahabusarakam W, Mecawun P, Phongpaichit S. Xanthones from the green branch of Garcinia dulcis. Nat Prod Res 2016; 1–6.
  49. Ito C, Miyamoto Y, Nakayama M, et al. A Novel Depsidon and Some New Xanthones from Garcinia Species. Chem Pharm Bull 1997; 45: 1403–1413.
  50. Kosela S, Hu L, Rachmatia T, et al. Dulxanthones F - H , Three New Pyranoxanthones from Garcinia dulcis. J Nat Prod 2000; 63: 406–407.
  51. Kosela S, Hu L, Yip S, et al. Dulxanthone E?: a pyranoxanthone from the leaves of Garcinia dulcis. Phytochemistry 1999; 52: 1375–1377.
  52. Ríos JL, Recio MC. Medicinal plants and antimicrobial activity. J Ethnopharmacol 2005; 100: 80–84.
  53. Chatterjee A, Yasmin T, Bagchi D, et al. The bactericidal effects of Lactobacillus acidophilus , garcinol and Protykin ® compared to clarithromycin , on Helicobacter pylori. Mol Cell Biochem 2003; 243: 29–35.
  54. Rao A S, Merugu R, Rao J M. Antibacterial And Antifungal Studies Of Prenylated Isoflavones And Prenylated 3-Aryl Coumarins Isolated From Derris scandens BENTH. J Pharmacogn 2012; 3: 51–54.
  55. Ibrahim MY, Hashim NM, Mariod AA, et al. a-Mangostin from Garcinia mangostana Linn: An updated review of its pharmacological properties. Arab J Chem 2016; 9: 317–329.
  56. Suksamrarn S, Suwannapoch N, Phakhodee W, et al. Antimycobacterial Activity of Prenylated Xanthones from the Fruits of Garcinia mangostana. Chem Pharm Bull (Tokyo) 2003; 51: 857–859.
  57. Sakagami Y, Iinuma M, Piyasena KGNP, et al. Antibacterial activity of a-mangostin against vancomycin resistant Enterococci (VRE) and synergism with antibiotics. Phytomedicine 2005; 12: 203–208.
  58. Nguyen PTM, Marquis RE. Antimicrobial actions of a-mangostin against oral streptococci. Can J Microbiol 2011; 57: 217–225.
  59. Ulanowska K, Tkaczyk A, Konopa G, et al. Differential antibacterial activity of genistein arising from global inhibition of DNA, RNA and protein synthesis in some bacterial strains. Arch Microbiol 2006; 184: 271–278.
  60. Koh JJ, Qiu S, Zou H, et al. Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting. Biochim Biophys Acta - Biomembr 2013; 1828: 834–844.