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Submitted
August 21, 2019
Accepted
April 30, 2020
Published
April 30, 2020
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Abstract

Parathyroid carcinoma is a rare cause of primary hyperparathyroidism. It often presents with unspecified clinical manifestation that leads to misdiagnosis. We report a case of a 36-year-old woman who suffered from multiple bone tumours and recurrent bone fracture for 3 years ago, and misdiagnosis as only a giant cell tumours of the bone. Then, the patient continued to develop another mass in the neck that kept growing and the mass move on swallowing. The clinician diagnosed her as a colloid goitre based on cytological examination from fine-needle aspiration biopsy. Elevated parathyroid hormone level, hypercalcemia, and suspected parathyroid adenoma in the Sestamibi Parathyroid scan led the clinician to perform a frozen section in this patient with subsequent histopathological of diagnosis as parathyroid carcinoma. The diagnosis of parathyroid carcinoma continues to be a challenge. Understanding the pathogenesis and multidisciplinary collaboration is important to define an accurate diagnosis and treatment. 

Keywords

Parathyroid carcinoma hypercalcemia primary hyperparathyroidism pathological fracture

Article Details

How to Cite
Usman, H. A., Agustina, H., Nurusshofa, Z., & Wahyuni, S. D. (2020). Diagnostic challenge in parathyroid carcinoma with multiple pathological bone fracture: A case report. JKKI : Jurnal Kedokteran Dan Kesehatan Indonesia, 11(1), 92–98. https://doi.org/10.20885/JKKI.Vol11.Iss1.art14
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References

  1. Givi B, Shah JP. Parathyroid carcinoma. Clinical Oncology. 2010;22(6):498-507.
  2. Llyod R, Osamura R, Kloppel G, Rosai J. WHO classification of tumours of endocrine organs. In: WHO, editor. Geneva: IARC; 2017. p. 147-52.
  3. Rizky P, Makes B. Parathyroid carcinoma: Review of a problematic case. Medical Journal of Indonesia. 2012;21(3):170-4.
  4. Mandal P, Ray S, Basu N. Parathyroid carcinoma uncovering enigma: Case report and review of literature. Journal of Cytology. 2011;28(4):223-5.
  5. Arnold A, Shattuck TM, Mallya SM, Krebs LJ, Costa J, Gallagher J, et al. Molecular pathogenesis of primary hyperparathyroidism. The Journal of Bone and Mineral Research. 2002;17 Suppl 2:N30-6.
  6. Ree F, Mitchele A, Gibson T. Parathyroid carcinoma: A case report and review of the literature. West Indian Medical Journal. 2015;64(3):305-8.
  7. Rosai J. Surgical pathology. In: Giordino T, editor. Parathyroid Gland. 2. 11 ed: Elsevier; 2018. p. 355-6.
  8. Rizwan A, Jamal A, Uzzaman M, Fatima S. Case report: lady with bone pains for 5 years-parathyroid carcinoma. BMC Research Notes. 2018;11(1):617.
  9. Cetani F, Pardi E, Marcocci C. Update on parathyroid cancer. Journal of Endocrinological Investigation. 2016;39:595–6.
  10. Suganuma N, Iwasaki H, Shimizu S. Non-functioning parathyroid carcinoma: A case report. Springer. 2017;3(81):15-8.
  11. Pramanik S, Ray S, Bhatarjee R, Chowdhury S. Parathyroid carcinoma and persistent hypercalcemia: A case report and review of therapeutic option. Saudi Journal of Medicine & Sciences. 2018;8(6):115-8.
  12. Rizwan A, Jamal A, Uzzaman M, Fatima S. Case report: Lady with bone pains for 5 years-parathyroid carcinoma. BMC Surgery. 2018;11(6):117-9.
  13. Fernandes JMP, Paiva C, Correia R, Polonia J, Moreira da Costa A. Parathyroid carcinoma: From a case report to a review of the literature. International Journal of Surgery Case Reports. 2018;42:214-7.
  14. Dagang DJ, Gutierrez JB, Sandoval MA, Lantion-Ang FL. Multiple brown tumours from parathyroid carcinoma. BMJ Case Reports. 2016;2016.
  15. Simonds WF. Parathyroid cancer and the CDC73 tumor suppressor gene. International Journal of Endocrine Oncology. 2014;1:59-69.