Article Sidebar

Submitted
October 13, 2019
Accepted
August 10, 2020
Published
August 31, 2020
Download
PDF Untitled (Bahasa Indonesia) (Bahasa Indonesia) (Bahasa Indonesia) (Bahasa Indonesia) (Bahasa Indonesia) (Bahasa Indonesia)
Statistic
Read Counter : 637 Download : 4853

Main Article Content

Abstract

Background: Gastric ulcer is a digestive problem that has a high prevalence rate, peptic ulcer can cause complications such as bleeding in the gastrointestinal tract, perforation, recurrence, cancer and even death. The neem stem bark extract has a compound that can be a gastroprotective activity so that it can reduce the number of gastric ulcer and gastric acid levels. Gastroprotective effects of neem bark extract in combination have been widely studied can reduce gastric ulcer, but no one has examined the extract of neem bark as a single gastroprotector.
Objective: This study aims to determine the dose of extract that can prove the extract of neem stem bark can inhibit the ulcer index by macroscopic observation and microscopic images of in rats
Methods: This research is a purely experimental study carried out in July – September 2019. The neem stem bark extract was given to Wistar male white rats with various dosages for seven days orally, after 24 hours of fasting, induced gastric ulcer with ibuprofen 400 mg/kg. Mice were dissected to activate the ulcer index after 8 hours of induction of gastric ulcer.
Result: The ulcus index of negative group (ibuprofen), positive group (ranidin), and extracts of mimba rods 250, 500, 1000, and 2000 CMG/kgBB in a row were 7.13, 16.76, 7.41, 2.32, and 2.00 (p= 0.034). Microscopic observations suggest a much better picture of histology after this extract.
Conclusion: The extract of a mimba bark has gastroprotective activity at 2,000 mg/kgBB.

Keywords

Azadirachta indica gastric ulcer ibuprofen Azadirachta indica Tukak Lambung Ibuprofen

Article Details

How to Cite
Nuraida, E., Sutiningsih, D., & Hadi, M. (2020). Effectiveness of neem (Azadirachta indica a.juss) bark extract as a gastroprotektor. JKKI : Jurnal Kedokteran Dan Kesehatan Indonesia, 11(2), 150–156. https://doi.org/10.20885/JKKI.Vol11.Iss2.art7
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. Li Z, Liao Z, McAlindon M. Handbook of capsule endoscopy.2014.
  2. Kemenkes RI. Profil kesehatan Indonesia (Demografi).2014.
  3. BPOM. Formulasi sediaan berbasis ekstrak. 2012;1:1-32.
  4. Hamid Nour A, Sandanasamy J, Hamid A, Nizam S, Hamid A. Chemical characterization and biological study of azadirachta indica extracts. European Journal of Academic Essays ISSN. 2014.
  5. Bandyopadhyay U, Biswas K, Sengupta A, et al. Clinical studies on the effect of neem (Azadirachta indica) bark extract on gastric secretion and gastroduodenal ulcer. Life Sciences. 2004;75(24):2867-78.
  6. Mediansyah A, Rahmanisa S. Hubungan ibuprofen terhadap tukak gaster. Journal Major. 2017;6:6-10.
  7. Sigit JI, Soemardji AA. Efektivitas preventif omeprazol terhadap efek samping tukak lambung antiinflamasi non steroid (asetosal) pada tikus galur wistar betina. Acta Pharmacy Indonesia. 2017;37(2):48-53.
  8. Sabiu S, O’Neill FH, Ashafa AOT. The purview of phytotherapy in the management of kidney disorders: A systematic review on Nigeria and South Africa. African Journal Traditional, Complementary and Alternative Medicines. 2016;13(5):38-47.
  9. Alturkistani HA, Tashkandi FM, Mohammedsaleh ZM. Histological stains?: A Literature review and case study. Global Journal of Health Science. 2016;8(3):72-79.
  10. Kuna L, Jakab J, Smolic R, Raguz-Lucic N, Vcev A, Smolic M. Peptic ulcer disease: a brief review of conventional therapy and herbal treatment options. Ournalicalic 2019;8(2):179.
  11. Riskha Kurnia Studi Aktivitas Antibakteri dan identifikasi fraksi teraktif daun mimba (azadirachta indica a . juss ) Skripsi. Universitas Sebelas Maret Surakarta. 2011.
  12. Alzohairy MA. Therapeutics role of azadirachta indica (neem) and their active constituents in diseases prevention and treatment. Evidence-based Complementary Alternative Medicine. 2016;2016.
  13. Fracon RN, Teófilo JM, Satin RB, Lamano T. Prostaglandins and bone: potential risks and benefits related to the use of nonsteroidal anti-inflammatory drugs in clinical dentistry. Journal of Oral Science. 2008;50(3):247-52.
  14. Madhulatha C, Sharaish P, Kalyani G, Sushma GS, Subramanian ns, devi ba. International journal of pharmacy & life s ciences anti-ulcer activity of pisonia aculeata on Pylorus ligation induced gastric ulcer in rats. International Journal of Pharmacy & Life Science. 2013;4(3):2440-2443.
  15. Elsharabasy FS, Al-mushhin AAM, Araffa S, Farrag ARH. Phytochemical screening and gastroprotective effect of the aerial parts of Salasola terrandra forssk . against aspirin induced gastric ulceration in rats. Journal Pharmacognosy and Phytochemictry. 2015;3(6):221-232.