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Background: A mucositis is the most common problem in a chemotherapy treatment and becomes a severe problem for patients who receive several cycles of chemotherapy. Effects of an oral mucositis that is not treated immediately or is less effective can affect quality of life of the patients. Pain experienced by them can cause problems in the mouth, for example inability to tolerate food or fluids (dysphagia) and decreases of nutritional status.
Objective: This study is to identify effectiveness of oral cryotherapy on prevention of the mucositis in cancer patients with chemotherapy.
Methods: This study used a quasi-experimental method with a pre and post-test for a control group. Its samples were 32 patients for an intervention group and a control group, taken by using a consecutive sampling technique. The mucositis was measured by using questionnaires of Oral Assessment Guide (OAG), and the obtained data was analysed by the Wilcoxon and Mann Whitney test.
Results: This study found that 24 respondents were not affected by the mucositis at p-value=0.008 (p<0.05) in the post intervention in the intervention group, and there was a difference in values of the mucositis measured by the OAG at p-value=0.003 (p<0.05) in the post intervention in the both groups.
Conclusion: The oral cryotherapy could prevent the mucositis in cancer patients with chemotherapy.


Oral cryotherapy Mucocities Cancer Chemotherapy

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How to Cite
Silaban, N. Y., Nasution, S. S., & Siregar, C. T. (2020). Influences of oral cryotherapy on mucositis prevention in cancer patients with chemotherapy. JKKI : Jurnal Kedokteran Dan Kesehatan Indonesia, 11(2), 165–171.


  1. International Agency for Research on Cancer (IARC). No Title [Internet]. 2012. Available from:
  2. (RISKESDAS) RKD. No Title [Internet]. 2016. Available from:
  3. Society AC. No Title [Internet]. 2017. Available from:
  4. Askarifar M, Lakdizaji S, Ramzi M, Rahmani A, Jabbarzadeh F. The effects of oral cryotherapy on chemotherapy-induced oral mucositis in patients undergoing autologous transplantation of blood stem cells: A clinical trial. Iranian Red Crescent Medical Journal. 2016;18(4).
  5. Cidon EU. Chemotherapy induced oral mucositis: Prevention is possible. Chinese Clinical Oncology. 2018;7(1).
  6. Gori E, Arpinati M, Bonifazi F, Errico A, Mega A, Alberani F, et al. Cryotherapy in the prevention of oral mucositis in patients receiving low-dose methotrexate following myeloablative allogeneic stem cell transplantation: A prospective randomized study of the Gruppo Italiano Trapianto di Midollo Osseo nurses group. Bone Marrow Transplant. 2007;39(6):347–52.
  7. Alvariño-Martín C, Sarrión-Pérez MG. Prevention and treatment of oral mucositis in patients receiving chemotherapy. Journal of Clinical and Experimental Dentistry. 2014;6(1):74–80.
  8. Okamoto K, Ninomiya I, Yamaguchi T, Terai S, Nakanuma S, Kinoshita J, et al. Oral cryotherapy for prophylaxis of oral mucositis caused by docetaxel, cisplatin, and fluorouracil chemotherapy for esophageal cancer. Esophagus. 2019;16(2):207–13.
  9. Riley P, Glenny AM, Worthington H V., Littlewood A, Clarkson JE, Mccabe MG. Interventions for preventing oral mucositis in patients with cancer receiving treatment: Oral cryotherapy. Cochrane database of systematic reviews. 2015;2015(2):9–10.
  10. Nawi RIM, Chui PL, Wan Ishak WZ, Hsien Chan CM. Oral cryotherapy: Prevention of oral mucositis and pain among patients with colorectal cancer undergoing chemotherapy. Clinical Journal of Oncology Nursing. 2018;22(5):555–60.
  11. Mubaraki S. Oral mucositis in children associated with hematopoietic stem cells transplant. Saudi Journal of Oral Sciences. 2019;6(2):47.
  12. Katranci N, Ovayolu N, Ovayolu O, Sevinc A. Evaluation of the effect of cryotherapy in preventing oral mucositis associated with chemotherapy - A randomized controlled trial. European Journal of Oncology Nursing. 2012;16(4):339–44.
  13. Peterson DE, Öhrn K, Bowen J, Fliedner M, Lees J, Loprinzi C, et al. Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy. Support Care Cancer. 2013;21(1):327–32.
  14. Svanberg A, Birgegård G, Öhrn K. Oral cryotherapy reduces mucositis and opioid use after myeloablative therapy - A randomized controlled trial. Support Care Cancer. 2007;15(10):1155–61.
  15. Caplinger J, Royse M, Martens J. Implementation of an Oral Care Protocol to promote early detection and management of stomatitis. Clinical Journal of Oncology Nursing. 2010;14(6):799–802.
  16. Karagözoglu S, Ulusoy MF. Chemotherapy: The effect of oral cryotherapy on the development of mucositis. Journal of Clinical Nursing. 2005;14(6):754–65.