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Submitted
January 20, 2021
Accepted
April 28, 2021
Published
August 31, 2021
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Abstract

Background : Antiretroviral (ARV) therapy is one of the efforts to combat HIV/AIDS in Indonesia, especially West Papua. One of the side effects using ARV is impaired liver function in People Living with HIV/AIDS (PLWHA). ARV therapy evaluation to liver disorders can be seen from the Serum Glutamic Oxaloacetic Transaminase (SGOT)/ Serum Glutamic Pyruvic Transaminase (SGPT) level.

Objective : To find out the effect of ARV Fixed Dosed Combination (FDC) to liver function of PLWHA patients in West Papua.

Methods : A cross-sectional study, involving 110 respondents who were PLWHA patients receiving ARV at Voluntary Counselling and Testing (VCT) service of hospital in Manokwari, Sorong, and Fak-fak. Laboratory tests was used to examine the liver function. Other variable data were obtained from medical records. The Fisher Exact Test with a significance level of <0.05 was used to determine the effect of ARV to liver function.

Results : Respondents had no liver problems with normal SGOT and SGPT values, i.e. 72,7% and 76.4%, respectively. While, the rest had mild and moderate toxicity. Respondent experiencing moderate toxicity was 2 patients who regularly took FDC in Sorong.

Conclussion : The FDC using in ARV therapy did not significantly influence the increase of SGOT and SGPT on PLWHA patients in West Papua.

Keywords

Fixed Dosed Combination liver function West Papua HIV/AIDS

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How to Cite
Widiyanti, M., Adiningsih, S., Natalia, E. I., & Purba, D. A. (2021). Effect of antiretroviral therapy to liver function of people living with HIV/AIDS patients in West Papua. JKKI : Jurnal Kedokteran Dan Kesehatan Indonesia, 12(2), 116–123. https://doi.org/10.20885/JKKI.Vol12.Iss2.art4
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