Main Article Content

Abstract

Typhoid, malaria, leptospirosis, dengue virus (DENV), and other arboviruses are endemic in Indonesia. Therefore, it is more likely that DENV and other infectious diseases could be coinfected. More severe symptoms, delayed identification, and ineffective treatment of the illness can all result from Salmonella typhi coinfection. To serve as a principle for clinicians’ considerations while diagnosing and prescribing, we aim to examine the immunopathogenesis of dengue associated with Salmonella typhi coinfection. Dengue virus has the potential to increase both susceptibility and incidence of this coinfection, leading to dengue haemorrhagic fever (DHF) with more severe clinical symptoms. This is explained by regulating impact of coinfection in the presence of gram-negative membrane endotoxin, DENV replication, and lipopolysaccharide (LPS). If Salmonella typhi coinfection is not treated promptly, both dengue and Salmonella typhi can affect several organs and result in significant morbidity and death. Dengue and typhoid immunopathogenesis coinfection are unclear. When dengue monoinfection compared with Salmonella dengue dual infections are related to higher fatality and morbidity rates.

Article Details

Author Biographies

Enny Nugraheni, Departement of Microbiology, Faculty of Medical dan Health Science, Universitas Bengkulu, Bengkulu, Indonesia/Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Indonesia

1. Medical Faculty and Health Science Universitas Bengkulu, Indonesia
2. Doctoral Program in Biomedical Science, Faculty of Medicine, Jakarta, Universitas Indonesia, Indonesia

Tjahjani Mirawati Sudiro, Departement of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Microbiology Departement, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Leonard Nainggolan, Department of Internal Medicine, dr. Cipto Mangunkusumo General National Hospital Jakarta/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Internal Medicine Departement, dr. Cipto Mangunkusumo General National Hospital Jakarta/Medical Faculty, Universitas Indonesia, Jakarta, Indonesia

 

Fithriyah, Departement of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Microbiology Departement, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

Beti Ernawati Dewi, Departement of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia/Infectious Disease and Immunology Cluster, Indonesian Medical Education and Research Institute Jakarta, Indonesia

Microbiology Departement, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

How to Cite
Nugraheni, E., Sudiro, T. M., Nainggolan, L., Fithriyah, & Dewi, B. E. (2024). Immunopathogenesis of dengue virus and Salmonella typhi coinfection. JKKI : Jurnal Kedokteran Dan Kesehatan Indonesia, 247–256. https://doi.org/10.20885/JKKI.Vol15.Iss2.art12