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Background: Osteoarthritis currently remains a significant health problem due to its high prevalence and morbidity rate. Radiological examination is still used as a gold standard to determine the severity of knee osteoarthritis by using Kellgren-Lawrence grading. Dextrose prolotherapy has been known to be effective in treating pain in knee osteoarthritis, but none has compared the efficacy between mild and moderate-severe knee osteoarthritis.
Objective: This study aims to compare the effectiveness of prolotherapy based on its radiological and symptomatic severity in knee osteoarthritis.
Methods: In this pre-post study, the participants who underwent dextrose prolotherapy injection (25% intra-articular and 15% periarticular) for three sessions with four weeks intervals were grouped into mild (grade 1-2) and severe (grade 3-4) groups. Participants’ functional status was measured with Western Ontario and McMaster Universities’ arthritis index scores at baseline and week 12.
Results: A total of 21 patients (average age 61.42 ± 8.33, BMI 26.81± 3.72) received three therapy sessions. Both groups had significantly better Western Ontario and McMaster Universities arthritis index scores than baseline (-22.57± 11.9; p = 0.002 and -15.42 ± 15.75; p = 0.003). All parameters were improved significantly (p <0.05) in both groups, except the stiffness score (p = 0.292; p = 0.057). There were no differences in functional outcome improvements in both groups (p > 0.05; CI 95%: -21.3 – 7.05).
Conclusion: Prolotherapy effectively improves functional outcomes in all stages of knee osteoarthritis.

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How to Cite
Waluyo, Y., Artika, S. R. ., Wahyuni, I. N. ., Adnan, E. ., Budu, & Bukhari, A. . (2023). Functional outcome in knee osteoarthritis after dextrose prolotherapy intervention: A severity-based pilot study. JKKI : Jurnal Kedokteran Dan Kesehatan Indonesia, 14(1), 47–54.