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Abstract

Background: Obesity is one of the cardiovascular disease risk factors that cause hypertrophy or hyperplasia of adipocytes. Changes in fat cells have the potential to increase inflammation and insulin resistance.
Objective: This study aims to determine the effects of high glucose, egg yolk consumption, calorie restriction, and air pollution on body weight, cell size, and fat tissue weight in rats.
Methods: The type of study is experimental and conducted for six weeks. Thirty white male rats were divided into five groups: sugar-treated group, egg yolk-treated group, restricted calorie intake-treated group, air pollutant-treated group, and control group. The cell size and weight of adipose tissue were obtained from abdominal and supraclavicular fat samples.
Results: High glucose, egg yolk consumption, air pollution exposure, and calorie restriction were affected by increases in body weight, cell size, and adipose tissue mass (p < 0.05). The cell size and weight of adipose tissue have a negative effect on body mass index. Nevertheless, dietary intervention studies have shown that the size of fat cells decreases after calorie restriction-induced weight loss.
Conclusion: The body weight, cell size, and adipose tissue weight of the rats were affected by a high sugar intake, egg yolk consumption, calorie restriction, and exposure to air pollution.

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How to Cite
Mukhtar, D., Royhan, A. ., Fitriani, H. L. ., Marantika, M. ., Salsabila, . D. S. ., Fitriyana, L. ., & Irwansyah, F. . (2023). Effects of high glucose, egg yolk intake, calorie restriction, and air pollution on rats’ fat cell. JKKI : Jurnal Kedokteran Dan Kesehatan Indonesia, 14(1), 61–68. https://doi.org/10.20885/JKKI.Vol14.Iss1.art10