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Abstract
Background: Vitamin D may potentially have a significant influence in managing obesity-related risk factors. The current evidence suggests that observational studies have found a negative correlation between leptin levels and serum vitamin D, but heterogeneous intervention studies have not shown a significant effect.
Objectives: This study aims to examine the effect of the combination of moderate-intensity continuous training (MICT) and vitamin D3 on leptin and anthropometry.
Methods: A true experimental, randomized pre and post-test control group design were performed on 36 subject (18 male and female each) for 12 weeks. A treatment group received MICT and vitamin D3, control group only received MICT and placebo. Both groups received moderate-intensity exercise (64-75% HR Max) with a frequency of 3x/week and a time of 60 minutes, carried out. In the treatment group, 5000 IU vitamin D3 was administered daily for 12 weeks, while the control group only received a placebo. In this study, hypothesis testing was conducted to compare the means of two independent groups using an independent t-test or Mann-Whitney test. For comparisons between two related groups, a paired t-test or the Wilcoxon Signed Rank Test was used.
Results: After conducting a test to compare two sample means from unrelated groups, statistically significant differences were observed between the treatment and control groups in this study. For the variables of BMI (p=0.025), waist circumference (p=0.042), body weight (p=0.008), leptin (p=0.015) and vitamin D3 (p<0.001).
Conclusion: Combination of vitamin D3 supplementation and MICT significantly lowered leptin and anthropometry in obese individuals.
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