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Abstract
ABSTRAK
Sel kanker merupakan sel yang memiliki karakteristik yang khas, yang mampu bertahan terhadap induksi apoptosis sel. Mitokondria merupakan organela yang berperan penting dalam induksi apoptosis sel pada jalur endogen.Pelepasan sitokrom C dan berbagai protein proapoptosis dari mitokondria ke sitoplasma dihambat oleh sel kanker melalui mekanisme stabilisasi permeabilitas mitokondria dan metabolic reprogramming.Dewasa ini telah dikembangkan berbagai terapi sel kanker berdasarkan target spesifik. Mitokondria merupakan salah satu target yang poten dalam terapi sel kanker. Dengan mengetahui karakteristik alamiah sel kanker terhadap mitokondria, diharapkan dapat dikembangkan terapi sel kanker berbasis organela spesifik (mitokondria) yang mampu meningkatkan apoptosis sel kanker tanpa mengakibatkan apoptosis pada sel normal.Naskah ini bertujuan untuk memahami lebih jauh bagaimana mekanisme sel kanker dalam memodulasi aktivitas mitokondria untuk dapat menghindari respon apoptosis sel, serta untuk mempelajari mekanisme terapi sel kanker berbasis mitokondria.
Kata kunci : sel kanker, permeabilitas mitokondria, metabolic reprogramming, apoptosis sel, sitokrom C, protein proapoptosis.
ABSTRACT
Cancer cells have distinct characteristics from normal cells, which able to withstand to cell apoptosis induction. Mitochondria are organelles that play an important role in the endogenous pathway of cells apoptosis. Release of cytochrome C and other proapoptosis proteins from the mitochondria to the cytoplasm were inhibit by cancer cells through mitochondrial permeability stabilization mechanism and metabolic reprogramming. Today various cancer cell therapies were developed on a specific targets. Mitochondria is a potent target in the treatment of cancer cells. By knowing the natural characteristics of mitochondrial cancer cells, a development of cell based cancer therapies by specific organelles were expected to increase cancer cells apoptosis without causing normal cells apoptosis. Aims of this manuscripstare to further understand about cancer cells mechanism in modulating mitochondrial activity to avoid mitochondrial apoptotic cells response, as well as to study the mechanism of cell based cancer therapies by mitokondria.
Keywords :cancer cells, mitochondrial permeability, metabolic reprogramming, cells apoptosis, cytocrome C, proapoptotic cells
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