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Disseminated nocardiosis is a rare and complicated opportunistic bacterial infection with propensity of delay in establishing the correct diagnosis and high frequency for misdiagnosis and due to the non-specific clinical presentation and the inherent difficulty in cultivating the organism. The infection is caused by gram-positive aerobic actinomycetes in the genus Nocardia. A definitive diagnosis requires the isolation and identification by Gram stain and modified acid-fast stain from a clinical specimen. Treatment heavily relies on species and susceptibility testing. There is a real paucity of prospective studies in nocardiosis infection, resulted in severely limited understanding of its diagnosis and treatment among the medical community. We report a clinical case of a 42-year old HIV-infected Burmese man with culture proven Nocardia infection.