Formulation peel-off gel mask of Impatiens balsamina l. as an antibactery against Staphylococcus aureus

Fitriani Mahyun, Aris Perdana Kusuma, Hady Anshory

Abstract

BackgroundAcne is a skin disorder characterised by inflammation, accompanied by a blockage of the oil glands in the skin. One of the causes of acne is Staphylococcus aureus bacteria. Many plants have been widely studied as an antibacterial agent, including Garden Balsam Leaf (Impatiens balsamina L.) which could be formulated in a peel-off gel preparation.

Objective : The purpose of this research was formulating an antibacterial peel-off gel mask with a variation of viscosity enhancing agent hydroxypropyl methylcellulose (HPMC), as well as testing its antibacterial activity on Staphylococcus aureus.

Methods : HPMC 1-2% was formulated in peel-off gel mask of Garden Balsam leaf extract. Physical properties such as viscosity, pH, spreadability, and drying time were tested, while antibacterial activity test was conducted by the agar-diffusion method.

Results : The viscosity of the entire formula was > 20,000 cP, pH 6, drying time > 20 minutes, and spreading power > 6 cm. Also, the peel-off gel mask also showed antibacterial activity on Staphylococcus aureus with average inhibition zone were > 10 mm, which indicated strong antibacterial inhibitory power.

ConclussionThe concentration variation of HPMC had a significant effect on all physical properties test. HPMC 1.5% in the preparation showed the most optimum results.

Keywords

Peel-off gel mask, Garden Balsam Leaf Extract (Impatiens balsamina L.), Staphylococcus aureus

Full Text:

PDF

References

Sekretariat Negara. Peraturan Pemerintah Republik Indonesia nomor 33 tahun 2012 tentang pemberian air susu ibu eksklusif. Jakarta: Pemerintah RI. 2012.

Indonesian Ministry of Health. Indonesian health statistics 2014. Kementerian Kesehatan Republik Indonesia. 2015. p. 40.

Dinas Kesehatan DIY. Profil kesehatan Kota Yogyakarta tahun 2013. Yogyakarta: Dinkes DIY. 2013.

Zarshenas M, Zhao Y, Poorarian S, Binns CW, Scott JA. Incidence and risk factors of mastitis in Shiraz, Iran: Results of a cohort study. Breastfeeding Medicine Journal. 2017;12(5):290–6.

Anasari T, Sumarni. Faktor-faktor yang mempengaruhi kejadian mastitis di RSUD Prof. Dr. Margono Soekarjo Purwokerto. Jurnal Involusi Kebidanan. 2014;4(7):40–52.

Sari SM. Hubungan pengetahuan ibu post partum tentang breast care dengan kejadian bendungan ASI pada ibu post partum. Jurnal Keperawatan dan Kebidanan - Stikes Dian Husada Mojokerto. 2017;81–6.

Jahanfar S, Ng CJ, Teng CL. Antibiotics for mastitis in breastfeeding women. Sao Paulo Medical Journal. 2016;134(3):273.

Hasanah AI, Hardiani RS, Susumaningrum LA. Hubungan teknik menyusui dengan risiko terjadinya mastitis pada ibu menyusui di Desa Kemuning Kecamatan Arjasa Kabupaten Jember (the correlation between breastfeeding techniques and risk of mastitis at Kemuning Village of Arjasa Distrincts Jember Regency). Pustaka Kesehatan. 2017;5(2):260–7.

Sastroasmoro S. Dasar-dasar metodologi penelitian klinis. 4th ed. Jakarta: Sagung Seto; 2011.

Scott JA, Robertson M, Fitzpatrick J, Knight C, Mulholland S. Occurrence of lactational mastitis and medical management: A prospective cohort study in Glasgow. International Breastfeeding Journal. 2008;3:6–11.

Mediano P, Fernández L, Rodríguez JM, Marín M. Case-control study of risk factors for infectious mastitis in Spanish breastfeeding women. Biomed Central Pregnancy and Childbirth. 2014;14(1):13–5.

Suresh S, Sharma K, Saksena M, Thukral A, Vatsa M, Agarwal R. Predictors of breastfeeding problems in the first postnatal week and its effect on exclusive breastfeeding rate at six months: Experience in a tertiary care centre in Northern India. Indian Journal of Public Health. 2014;58(4):270.

Dutta R, Gowder RO. The prevalence and predisposing factors of mastitis in lactating mothers in puerperium. The New Indian Journal of OBGYN. 2018;5(1):28–32.

Soekidjo N. Promosi kesehatan dan ilmu perilaku. Jakarta: Rineka Cipta; 2010.

Jain S, Parman V, Singla M, Azac C. Problems of breast feeding from birth till discharge--experience in a medical college in Chandigarh. Indian Journal of Public Health. 2009;53(4):264.

WHO. Mastitis: Penyebab dan penatalaksanaan. Alih Bahasa. Sugiarto B, Adiningsih D, Santoso LA, editors. Jakarta: Widya Medika; 2002.