BIOACTIVE CONSTITUENTS FROM THE LEAVES OF MELASTOMA MALABATHRICUM L.
Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L.
(Melastomataceae) have been investigated. The n-hexane extract yielded ï¡-amyrin, patriscabatrine
and auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gave
quercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts and
isolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidant
assay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op-
trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition more
than 90% in the FTC method. Quercetin was found to be the most active as radical scavenger in
DPPH method with IC50 of 0.69 ï¡M. ï¡-Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl)
glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPA
mouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively.
Keywords: Antiinflammatory, Antioxidant, Flavonoids, Melastomataceae, Melastoma
Jurnal Ilmiah Farmasi (JIF)
Department of Pharmacy, Faculty of Mathematics and Science,
Universitas Islam Indonesia.
JIF at http://journal.uii.ac.id/JIF/ is licensed under a Creative Commons Attribution 4.0 International License.