BIOACTIVE CONSTITUENTS FROM THE LEAVES OF MELASTOMA MALABATHRICUM L.

Deni Susanti, Hasnah M. Sirat, Farediah Ahmad, Rasadah Mat Ali

Abstract

ABSTRACT
Phytochemical and bioactivity studies of the leaves of Melastoma malabathricum L.
(Melastomataceae) have been investigated. The n-hexane extract yielded ï¡-amyrin, patriscabatrine
and auranamide, ethyl acetate extract gave quercetin and quercitrin, and methanol extract gave
quercitrin and kaempferol-3-O-(2”,6”-di-O-p-trans-coumaroyl)glucoside. The crude extracts and
isolated compounds were screened for their antioxidant and cytotoxic activities. The antioxidant
assay was carried out by FTC and DPPH radical scavenging method. Kaempferol-3-O-(2”,6”-di-Op-
trans-coumaroyl)-glucoside, quercetin and quercitrin showed strong activities with inhibition more
than 90% in the FTC method. Quercetin was found to be the most active as radical scavenger in
DPPH method with IC50 of 0.69 ï¡M. ï¡-Amyrin and kaempferol-3-O-(2”,6”-di-O-p-transcoumaroyl)
glucoside demonstrated the strongest activities in the anti-inflammatory assay of TPA
mouse ear oedema with IC50 of 0.11 and 0.34 mM/ear, respectively.

Keywords: Antiinflammatory, Antioxidant, Flavonoids, Melastomataceae, Melastoma
malabathricum, Terpenoid

Full Text:

PDF




Jurnal Ilmiah Farmasi (JIF)
Published by:
Department of Pharmacy, Faculty of Mathematics and Science,
Universitas Islam Indonesia.

ISSN 1693-8666

Creative Commons License
JIF at  http://journal.uii.ac.id/JIF/ is licensed under a Creative Commons Attribution 4.0 International License.