Article Sidebar
Main Article Content
Abstract
Latar Belakang : Cengkeh merupakan tanaman rempah asli dari Indonesia. Tanaman ini digunakan sebagai obat tradisional berbagai penyakit karena senyawa yang terkandung memiliki sifat sebagai anti inflamasi, antimikroba dan antioksidan pada berbagai sistem tubuh, salah satunya adalah sistem imun. Limfosit dan makrofag merupakan komponen penting dalam mekanisme pertahanan tubuh. Makrofag berperan dalam pertahanan pertama dan limfosit sebagai pertahanan berikutnya. Kedua sel ini saling berhubungan dan berkomunikasi melalui sitokin sehingga patogen didalam tubuh dapat dieliminasi.
Tujuan : Studi ini bertujuan mengkaji efek ekstrak terhadap sel limfosit dan makrofag sebagai mekanisme pertahanan.
Metode : Berbagai literatur fulltext berbahasa inggris dan Indonesia dengan rentang tahun 2006-2019 digunakan sebagai referensi penulisan artikel. Literatur didapatkan dari alat pencarian pubmed dan google scholar dengan kata kunci “clove”, “lymphocytes”, “macrophage”, dan “immunodulator”
Pembahasan : Studi literature menunjukkan bahwa ekstrak cengkeh memiliki efek immunodulator dengan dose dependent. Ketika dosis kecil diberikan (<1µg/mL) terjadi penurunan oksidan NO dan iNOS oleh makrofag yang teraktivasi oleh LPS. Sedangkan dosis tinggi (100-1000µg/mL) menunjukkan peningkatan marker inflamasi pada makrofag tak teraktivasi.
Kesimpulan : Ekstrak cengkeh memiliki efek immunodulator pada kadar limfosit dan makrofag sesuai dengan keadaan tubuh.
Kata kunci : Eugenol, Limfosit, Makrofag, Respon Imun
Article Details
1. Proposed Policy for Journals That Offer Open Access
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
2. Proposed Policy for Journals That Offer Delayed Open Access
Authors who publish with this journal agree to the following terms:- Authors retain copyright and grant the journal right of first publication, with the work [SPECIFY PERIOD OF TIME] after publication simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).