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Abstract
This study aims to determine the effect of High-Density Lipoprotein (VCO) dose on mice's blood serum High-Density Lipoprotein (HDL) levels. This study is an experimental study using 24 mice divided into four groups. Control (-), Control (+) were fed egg yolks 0.025 mL/g body weight, Dose 0.02 and Dose 0.025 were experimental groups, given egg yolks 0.025 mL/g mice body weight and VCO at a dose of 0.020 mL, and 0.025 mL/g body weight of mice. HDL levels were determined on days 7, 14, and 21 by enzymatic method using 20 D* spectrophotometry. The statistical test found that the length of time giving VCO significantly affected blood serum HDL levels in mice with Fcount > Ftable (Fcount = 7.128 and Ftable = 5.14). In contrast, variations in VCO dose did not significantly affect blood serum HDL levels. mice with Fcount < Ftable (Fcount = 3.33 and Ftable = 4.76). The highest HDL level was at a dose of 0.020 mL/g body weight of mice with a treatment period of 14 days, namely 164,033 mg/dL of blood.
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References
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- W. Kristina, “The Effectiveness of The Combination Of Red Dragon Fruit Juice with Virgin Coconut Oil To Cholesterol Levels In Sprague Dawley Rats Dyslipidemia,” Politeknik Negeri Jember, 2020.
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- P. Sibuea, “Coconut Oil Penyembuh Ajaib dari Buah Kelapa,” J. Medan Unika St. Thomas, 2004.
- B. Fife, “How Do You Identify a Good Quality Coconut Oil,” Healthy Ways Newsletter, 2005.
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- B. Rahmadi, A., & Bohari, Pangan Fungsional Berkhasiat Antioksidan. 2018.
- R. Sayuti, K., & Yenrina, Antioksidan alami dan sintetik. padang: Universitas Andalas, 2015.
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- U. Nurrahmania, Stop! Kolestrol Tinggi. Yogyakarta: Falimia Group Relasi Intimeda, 2012.
- V. L. Brashers, Aplikasi klinis patofisiologi: pemeriksaan dan manajemen, 2nd ed. Jakarta: Penerbit Buku Kedokteran EGC, 2003.
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References
Direktorat Jendral Perkebunan, “Statistic Perkebunan Indonesia Kelapa 2015- 2017,” Jakarta, 2016.
L. Marlina, Marlina and Wijayanti, Dwi and Yudiastari, Ivo Pangesti and Safitri, “Pembuatan Virgin Coconut Oil dari Kelapa Hibrida Menggunakan Metode Penggaraman dengan NaCl dan Garam Dapur,” J. Chemurg., vol. 1, no. 2, pp. 7–12, 2018.
N. A. A. Ghani, A. A. Channip, P. Chok Hwee Hwa, F. Ja’afar, H. M. Yasin, and A. Usman, “Physicochemical properties, antioxidant capacities, and metal contents of virgin coconut oil produced by wet and dry processes,” Food Sci. Nutr., vol. 6, no. 5, pp. 1298–1306, 2018, doi: 10.1002/fsn3.671.
dan H. R. Sutarmi, Taklukkan penyakit dengan VCO. Jakarta: Penebar Swadaya, 2005.
M. Yuniwati et al., “Pemanfaatan Jeruk Nipis ( Citrus Aurantifolia ) Pada Pebuatan Virgin Coconut Oil ( VCO ) Dari Santan Kelapa,” pp. 64–71.
K. DIAH, “PENGARUH KONSENTRASI STARTER TERHADAP SIFAT FISIKOKIMIA VCO ( Virgin Coconut Oil ) KELAPA BIBIR MERAH ( Cocos nucifera L Var rubescens ),” Doctoral dissertation, UNIVERSITAS ISLAM NEGERI RADEN INTAN LAMPUNG, 2021.
L. C. and others Dali, Arniah and Simbiti, “Pengaruh Kecepatan Putar Pengadukan Dan Waktu Pendiaman Terhadap Rendemen Dan Kualitas Minyak Kelapa Murni (VCO),” Al-Kimia, vol. 3, no. 2, pp. 48–58, 2015.
W. Kristina, “The Effectiveness of The Combination Of Red Dragon Fruit Juice with Virgin Coconut Oil To Cholesterol Levels In Sprague Dawley Rats Dyslipidemia,” Politeknik Negeri Jember, 2020.
T. Aziz, Y. Olga, and A. P. Sari, “Pembuatan virgin coconut oil (VCO) dengan metode penggaraman,” J. Tek. Kim., vol. 23, no. 2, pp. 129–136, 2017.
Z. Gani and Dkk, “Bebas Segala Penyakit Dengan VCO,” Jakarta: Puspa Swara, 2005.
P. Sibuea, “Coconut Oil Penyembuh Ajaib dari Buah Kelapa,” J. Medan Unika St. Thomas, 2004.
B. Fife, “How Do You Identify a Good Quality Coconut Oil,” Healthy Ways Newsletter, 2005.
K. G. Nevin and T. Rajamohan, “Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation,” Clin. Biochem., vol. 37, no. 9, pp. 830–835, 2004, doi: 10.1016/j.clinbiochem.2004.04.010.
K. G. Nevin and T. Rajamohan, “Effect of topical application of virgin coconut oil on skin components and antioxidant status during dermal wound healing in young rats,” Skin Pharmacol. Physiol., vol. 23, no. 6, pp. 290–297, 2010, doi: 10.1159/000313516.
B. Rahmadi, A., & Bohari, Pangan Fungsional Berkhasiat Antioksidan. 2018.
R. Sayuti, K., & Yenrina, Antioksidan alami dan sintetik. padang: Universitas Andalas, 2015.
I. G. M. Aman, “Makanan Sebagai Sumber Antioksidan,” Bali Heal. J., vol. 1, no. 1, pp. 49–55, 2017.
K. K. R. I. (Kemenkes RI), “Riset Kesehatan Dasar (Riskesdas),” Badan Penelitian dan Pengembangan Kesehatan Kementrian Kesehatan Republik Indonesia, 2018. .
A. Nur, “Virgin Coconut Oil, Minyak Penakluk Aneka Penyakit,” Jakarta: Agromedia Pustaka, 2005, p. 45.
U. Nurrahmania, Stop! Kolestrol Tinggi. Yogyakarta: Falimia Group Relasi Intimeda, 2012.
V. L. Brashers, Aplikasi klinis patofisiologi: pemeriksaan dan manajemen, 2nd ed. Jakarta: Penerbit Buku Kedokteran EGC, 2003.
Anies, Kolesterol dan penyakit jantung koroner. Yogyakarta: Ar-Ruzz Media, 2015.
R. Murray, D. Granner, and V. Rodwell, “Biokimia Harper, Edisi ke-27,” CV. ECG, Jakarta, 2009.
1.1, “The Effectiveness of The Combination Of Red Dragon Fruit Juice with Virgin Coconut Oil To Cholesterol Levels In Sprague Dawley Rats Dyslipidemia,” Angew. Chemie Int. Ed. 6(11), 951–952., 1967.
R. E. Wildman, R. Wildman, and T. C. Wallace, Handbook of nutraceuticals and functional foods. CRC press, 2016.