Article Sidebar
Downloads
Main Article Content
Abstract
Background: Annona muricata L. (A. muricata) leaf contains several active compounds, including flavonoids, which are known to have antioxidant properties. People only use A. muricata leaves as antioxidants by boiling them in water. Therefore, the development of tablet potential is necessary to enhance user comfort and storage stability.
Objective: The aim of this research was to determine the disintegration time of A. muricata leaf extract tablets with varying levels of the disintegrating agent crospovidone and to determine the best disintegrating level according to the results of evaluating the physical properties of the tablets.
Methods: Tablets are made using the wet granulation method with a composition of 2-5% crospovidone. The resulting granules are tested for water content, flow time, angle of repose, and tapping. The resulting tablets were tested for hardness, friability, and disintegration time.
Results: The test results show that crospovidone and lactose can produce excellent A. muricata leaf extract tablets.
Conclusion: Crospovidone 3.5% produces optimum A. muricata leaf extract tablets with a friability of 0.36% and a disintegration time of 7.82 minutes.
Keywords
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish in the Jurnal Ilmiah Farmasi agree to the following terms:
- Authors retain copyright and grant Jurnal Ilmiah Farmasi right of first publication with the work simultaneously licensed under a Creative Commons Attribution Licence that allows others to adapt (remix, transform, and build) upon the work non-commercially with an acknowledgement of the work's authorship and initial publication in Jurnal Ilmiah Farmasi.
- Authors are permitted to share (copy and redistribute) the journal's published version of the work non-commercially (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in Jurnal Ilmiah Farmasi.
References
- Adewole. S.. and Caxton-Martins. E. (2009): Morphological changes and hypoglycemic effects of Annona muricata linn. (annonaceae) leaf aqueous extract on pancreatic β-cells of streptozotocin-treated diabetic rats. African Journal of Biomedical Research. 9(3). 173–187. https://doi.org/10.4314/ajbr.v9i3.48903
- Alkrad. J. A.. Abu Shmeis. R.. Alshwabkeh. I.. Abazid. H.. and Mohammad. M. A. (2017): Investigation of the potential application of sodium bentonite as an excipient in formulation of sustained release tablets. Asian Journal of Pharmaceutical Sciences. 12(3). 259–265. https://doi.org/10.1016/j.ajps.2017.01.004
- Apriliana. C. A. (2021): Formulasi Dan Evaluasi Tablet Ekstrak Etanol Daun Sirsak (Annona muricata L.) Dengan Variasi Konsentrasi Primojel Sebagai Penghancur. Universitas Syiah Kuala.
- Awaluddin. R.. Prasetya. A. W.. Nugraha. Y.. Suweleh. M. F.. Kusuma. A. P.. and Indrati. O. (2017): Physical modification and characterization of starch using pregelatinization and co-process of various tubers from Yogyakarta as an excipient. AIP Conference Proceedings. 1823. https://doi.org/10.1063/1.4978184
- Badmus. J. A.. Oyemomi. S. A.. Adedosu. O. T.. Yekeen. T. A.. Azeez. M. A.. Adebayo. E. A.. Lateef. A.. Badeggi. U. M.. Botha. S.. Hussein. A. A.. and Marnewick. J. L. (2020): Photo-assisted bio-fabrication of silver nanoparticles using Annona muricata leaf extract: exploring the antioxidant. anti-diabetic. antimicrobial. and cytotoxic activities. Heliyon. 6(11). e05413. https://doi.org/10.1016/j.heliyon.2020.e05413
- Endriyatno. N. C. (2018): Optimasi Formula Tablet Ekstrak Daun Sirsak (Annona muricata L.) Dengan Bahan Pengikat CMC Na Dan Penghancur Explotab Menggunakan Metode Factorial Design. Universitas Muhammadiyah Surakarta.
- Gabbott. I. P.. Al Husban. F.. and Reynolds. G. K. (2016): The combined effect of wet granulation process parameters and dried granule moisture content on tablet quality attributes. European Journal of Pharmaceutics and Biopharmaceutics. 106. 70–78. https://doi.org/https://doi.org/10.1016/j.ejpb.2016.03.022
- Goh. H. P.. Heng. P. W. S.. and Liew. C. V. (2017): Understanding die fill variation during mini-tablet production. International Journal of Pharmaceutics. 534(1–2). 279–286. https://doi.org/10.1016/j.ijpharm.2017.10.042
- Kaleemullah. M.. Jiyauddin. K.. Thiban. E.. Rasha. S.. Al-Dhalli. S.. Budiasih. S.. Gamal. O. E.. Fadli. A.. and Eddy. Y. (2017): Development and evaluation of Ketoprofen sustained release matrix tablet using Hibiscus rosa-sinensis leaves mucilage. Saudi Pharmaceutical Journal. 25(5). 770–779. https://doi.org/10.1016/j.jsps.2016.10.006
- Lalojawa. A. (2017): Optimasi formula tablet ekstrak daun sirsak (Annona muricata L.) menggunakan PVP K-30 sebagai pengikat dan Ac-Di-Sol sebagai penghancur. Universitas Widya Mandala.
- Lamešić. D.. Planinšek. O.. Lavrič. Z.. and Ilić. I. (2017): Spherical agglomerates of lactose with enhanced mechanical properties. International Journal of Pharmaceutics. 516(1–2). 247–257. https://doi.org/10.1016/j.ijpharm.2016.11.040
- Martinello. T.. Kaneko. T. M.. Velasco. M. V. R.. Taqueda. M. E. S.. and Consiglieri. V. O. (2006): Optimization of poorly compactable drug tablets manufactured by direct compression using the mixture experimental design. International Journal of Pharmaceutics. 322(1–2). 87–95. https://doi.org/10.1016/j.ijpharm.2006.05.034
- Oktavianus. D. (2017): Optimasi Formula Tablet Ekstrak Daun Sirsak (Annona muricata L.) Menggunakan PVP K-30 Sebagai Pengikat Dan Crospovidone Sebagai Penghancur. Universitas Katolik Widya Mandala.
- Silviani. E.. Prasetyorini. and Andini. S. (2021): Formulasi Sediaan Fast Disintegrating Tablet (FDT) Ekstrak Buah Sirsak (Annona muricata L.) Dengan Variasi Superdisintegran Sebagai Penghancur. Universitas Pakuan.
- USP (2016): The United States Pharmacopeia 39-The National Formulary 34.
References
Adewole. S.. and Caxton-Martins. E. (2009): Morphological changes and hypoglycemic effects of Annona muricata linn. (annonaceae) leaf aqueous extract on pancreatic β-cells of streptozotocin-treated diabetic rats. African Journal of Biomedical Research. 9(3). 173–187. https://doi.org/10.4314/ajbr.v9i3.48903
Alkrad. J. A.. Abu Shmeis. R.. Alshwabkeh. I.. Abazid. H.. and Mohammad. M. A. (2017): Investigation of the potential application of sodium bentonite as an excipient in formulation of sustained release tablets. Asian Journal of Pharmaceutical Sciences. 12(3). 259–265. https://doi.org/10.1016/j.ajps.2017.01.004
Apriliana. C. A. (2021): Formulasi Dan Evaluasi Tablet Ekstrak Etanol Daun Sirsak (Annona muricata L.) Dengan Variasi Konsentrasi Primojel Sebagai Penghancur. Universitas Syiah Kuala.
Awaluddin. R.. Prasetya. A. W.. Nugraha. Y.. Suweleh. M. F.. Kusuma. A. P.. and Indrati. O. (2017): Physical modification and characterization of starch using pregelatinization and co-process of various tubers from Yogyakarta as an excipient. AIP Conference Proceedings. 1823. https://doi.org/10.1063/1.4978184
Badmus. J. A.. Oyemomi. S. A.. Adedosu. O. T.. Yekeen. T. A.. Azeez. M. A.. Adebayo. E. A.. Lateef. A.. Badeggi. U. M.. Botha. S.. Hussein. A. A.. and Marnewick. J. L. (2020): Photo-assisted bio-fabrication of silver nanoparticles using Annona muricata leaf extract: exploring the antioxidant. anti-diabetic. antimicrobial. and cytotoxic activities. Heliyon. 6(11). e05413. https://doi.org/10.1016/j.heliyon.2020.e05413
Endriyatno. N. C. (2018): Optimasi Formula Tablet Ekstrak Daun Sirsak (Annona muricata L.) Dengan Bahan Pengikat CMC Na Dan Penghancur Explotab Menggunakan Metode Factorial Design. Universitas Muhammadiyah Surakarta.
Gabbott. I. P.. Al Husban. F.. and Reynolds. G. K. (2016): The combined effect of wet granulation process parameters and dried granule moisture content on tablet quality attributes. European Journal of Pharmaceutics and Biopharmaceutics. 106. 70–78. https://doi.org/https://doi.org/10.1016/j.ejpb.2016.03.022
Goh. H. P.. Heng. P. W. S.. and Liew. C. V. (2017): Understanding die fill variation during mini-tablet production. International Journal of Pharmaceutics. 534(1–2). 279–286. https://doi.org/10.1016/j.ijpharm.2017.10.042
Kaleemullah. M.. Jiyauddin. K.. Thiban. E.. Rasha. S.. Al-Dhalli. S.. Budiasih. S.. Gamal. O. E.. Fadli. A.. and Eddy. Y. (2017): Development and evaluation of Ketoprofen sustained release matrix tablet using Hibiscus rosa-sinensis leaves mucilage. Saudi Pharmaceutical Journal. 25(5). 770–779. https://doi.org/10.1016/j.jsps.2016.10.006
Lalojawa. A. (2017): Optimasi formula tablet ekstrak daun sirsak (Annona muricata L.) menggunakan PVP K-30 sebagai pengikat dan Ac-Di-Sol sebagai penghancur. Universitas Widya Mandala.
Lamešić. D.. Planinšek. O.. Lavrič. Z.. and Ilić. I. (2017): Spherical agglomerates of lactose with enhanced mechanical properties. International Journal of Pharmaceutics. 516(1–2). 247–257. https://doi.org/10.1016/j.ijpharm.2016.11.040
Martinello. T.. Kaneko. T. M.. Velasco. M. V. R.. Taqueda. M. E. S.. and Consiglieri. V. O. (2006): Optimization of poorly compactable drug tablets manufactured by direct compression using the mixture experimental design. International Journal of Pharmaceutics. 322(1–2). 87–95. https://doi.org/10.1016/j.ijpharm.2006.05.034
Oktavianus. D. (2017): Optimasi Formula Tablet Ekstrak Daun Sirsak (Annona muricata L.) Menggunakan PVP K-30 Sebagai Pengikat Dan Crospovidone Sebagai Penghancur. Universitas Katolik Widya Mandala.
Silviani. E.. Prasetyorini. and Andini. S. (2021): Formulasi Sediaan Fast Disintegrating Tablet (FDT) Ekstrak Buah Sirsak (Annona muricata L.) Dengan Variasi Superdisintegran Sebagai Penghancur. Universitas Pakuan.
USP (2016): The United States Pharmacopeia 39-The National Formulary 34.