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November 20, 2024
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December 17, 2024
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December 31, 2024
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Abstract

Background: Essential oils (EO), such as lavender (Lavandula spp.), which are derived from its flower, have become a growing trend in recent years as an alternative medicine in therapy. However, the poor physicochemical properties of EOs have several disadvantages for their application. Integrating nanotechnology into the formulation of medicinal dosage forms may provide a viable way to mitigate these limitations and improve the effectiveness of EO utilization.
Objective: This literature review aims to gather information on the medicinal benefits of lavender EO and the prospective applications of nanotechnology-based delivery systems for EOs.
Method: Online databases such as PubMed, Science Direct, Research Gate, Google Scholar, and other reliable sources were used to find 65 publications between 1991 and 2021, which are assessed in this review.
Results: It is revealed that the main constituents of lavender EO are linalool, linalyl acetate, and lavandulyl acetate. Its effectiveness as an antibacterial, antioxidant, anticancer, anti-anxiety, and having effects on the central nervous system, along with other qualities including pain relief, has been demonstrated via numerous studies. Additionally, it was demonstrated to have dermatological properties that helped treat dermatitis and encouraged both hair growth and wound healing. Furthermore, it was also found that the application of nanotechnology in EOs has improved the concentration of active compounds in the blood and produced a stable dosage form while also increasing its efficacy.
Conclusion: It is feasible to create nanoparticle dosage forms from lavender EO that can improve the substance's solubility, stability, and pharmacological effects. More research is necessary to formulate lavender EO by applying nanotechnology.

Keywords

lavender essential oil therapeutic activity nanotechnology nanoparticle

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References

  1. Adaszyńska, M., Swarcewicz, M., Dzięcioł, M., & Dobrowolska, A. (2013). Comparison of Chemical Composition and Antibacterial Activity of Lavender Varieties from Poland. Natural Product Research, 27(16), 1497–1501. https://doi.org/10.1080/14786419.2012.724408
  2. Alexander, A., Ajazuddin, Patel, R.J., Saraf, Swarnlata, & Saraf, Shailendra. (2016). Recent Expansion of Pharmaceutical Nanotechnologies and Targeting Strategies In The Field of Phytopharmaceuticals For The Delivery of Herbal Extracts and Bioactives. Journal of Controlled Release, 241, 110–124. https://doi.org/10.1016/j.jconrel.2016.09.017
  3. Ali, B., Al-Wabel, N.A., Shams, S., Ahamad, A., Khan, S.A., & Anwar, F. (2015). Essential Oils Used In Aromatherapy: A Systemic Review. Asian Pacific Journal of Tropical Biomedicine, 5(8), 601–611. https://doi.org/10.1016/j.apjtb.2015.05.007
  4. Anderson, C., Lis-Balchin, M., & Kirk-Smith, M. (2000). Evaluation of Massage With Essential Oils On Childhood Atopic Eczema. Phytotherapy Research, 14(6), 452–456. https://doi.org/10.1002/1099-1573(200009)14:6<452::AID-PTR952>3.0.CO;2-4
  5. Bodnar, R.J. (2013). Epidermal Growth Factor and Epidermal Growth Factor Receptor: The Yin and Yang in the Treatment of Cutaneous Wounds and Cancer. Advances in Wound Care, 2(1), 24–29. https://doi.org/10.1089/wound.2011.0326
  6. Buchbauer, G., Jirovetz, L., & Jäger, W. (1991). Aromatherapy: Evidence for Sedative Effects of the Essential Oil of Lavender after Inhalation. Zeitschrift für Naturforschung C, 46c, 1067–1072. https://doi.org/10.1515/znc-1991-11-1223
  7. Calcabrini, A., Stringaro, A., Toccacieli, L., Meschini, S., Marra, M., Colone, M., Arancia, G., Molinari, A., Salvatore, G., & Mondello, F. (2004). Terpinen-4-ol, The Main Component of Melaleuca Alternifolia (Tea Tree) Oil Inhibits the In Vitro Growth of Human Melanoma Cells. Journal of Investigative Dermatology, 122(2), 349–360. https://doi.org/10.1046/j.0022-202X.2004.22236.x
  8. Cavanagh, H.M.A., & Wilkinson, J.M. (2002). Biological Activities of Lavender Essential Oil. Phytotherapy Research, 16(4), 301–308. https://doi.org/10.1002/ptr.1103
  9. De Groot, A., & Schmidt, E. (2016). Essential Oils, Part V: Peppermint Oil, Lavender Oil, and Lemongrass Oil. Dermatitis, 27(6), 325–332. https://doi.org/10.1097/DER.0000000000000218
  10. Diego, M.A., Jones, N.A., Field, T., Hernandez-reif, M., Schanberg, S., Kuhn, C., Galamaga, M., McAdam, V., & Galamaga, R. (1998). Aromatherapy Positively Affects Mood, Eeg Patterns of Alertness and Math Computations. International Journal of Neuroscience, 96(3-4), 217–224. https://doi.org/10.3109/00207459808986469
  11. Dunn, C., Sleep, J., & Collett, D. (1995). Sensing An Improvement: An Experimental Study To Evaluate The Use of Aromatherapy, Massage and Periods of Rest In An Intensive Care Unit. Journal of Advanced Nursing, 21(1), 34–40. https://doi.org/10.1046/j.1365-2648.1995.21010034.x
  12. Dunning, T. (2013). Aromatherapy: Overview, Safety and Quality Issues. OA Alternative Medicine, 1(1). https://doi.org/10.13172/2052-7845-1-1-518
  13. Fadel, B.A., Elwakil, B.H., Fawzy, E.E., Shaaban, M.M., & Olama, Z.A. (2023). Nanoemulsion of Lavandula angustifolia Essential Oil/Gold Nanoparticles: Antibacterial Effect against Multidrug-Resistant Wound-Causing Bacteria. Molecules, 28(19), 6988-7004. https://doi.org/10.3390/molecules28196988
  14. Fahimnia, F., Nemattalab, M., & Hesari, Z. (2024). Development and Characterization of A Topical Gel, Containing Lavender (Lavandula angustifolia) Oil Loaded Solid Lipid Nanoparticles. BMC Complement Medicine and Therapies, 24(155), 1-12. https://doi.org/10.1186/s12906-024-04440-2
  15. Ghelardini, C., Galeotti, N., Salvatore, G., & Mazzanti, G. (1999). Local Anaesthetic Activity of the Essential Oil of Lavandula angustifolia. Planta Medica, 65(8), 700–703. https://doi.org/10.1055/s-1999-14045
  16. Hanamanthagouda, M.S., Kakkalameli, S.B., Naik, P.M., Nagella, P., Seetharamareddy, H.R., & Murthy, H.N. (2010). Essential Oils of Lavandula bipinnata and Their Antimicrobial Activities. Food Chemistry, 118(3), 836–839. https://doi.org/10.1016/j.foodchem.2009.05.032
  17. Harwansh, R.K., Patra, K.C., & Pareta, S.K. (2011a). Nanoemulsion As Potential Vehicles For Transdermal Delivery of Pure Phytopharmaceuticals and Poorly Soluble Drug. International Journal of Drug Delivery, 3, 209-218.
  18. Harwansh, R.K., Patra, K.C., Pareta, S.K., Singh, J., & Rahman, M.A. (2011b). Nanoemulsions As Vehicles For Transdermal Delivery of Glycyrrhizin. Brazilian Journal of Pharmaceutical Sciences, 47(4), 769–778. https://doi.org/10.1590/S1984-82502011000400014
  19. Hay, I.C., Jamieson, M., & Ormerod, A.D. (1998). Randomized Trial of Aromatherapy: Successful Treatment for Alopecia Areata. Arch Dermatol, 134(11), 1349-1352. https://doi.org/10.1001/archderm.134.11.1349
  20. Hudson, R., 1995. Use of Lavender In A Long-Term Elderly Ward. Nursing Times 91, 12.
  21. Hui, L., He, L., Huan, L., XiaoLan, L., & AiGuo, Z. (2010). Chemical Composition of Lavender Essential Oil and Its Antioxidant Activity and Inhibition Against Rhinitis-Related Bacteria. African Journal of Microbiology Research, 4(4), 309–313.
  22. Kim, H.-M., & Cho, S.-H. (2010). Lavender Oil Inhibits Immediate-type Allergic Reaction in Mice and Rats. Journal of Pharmacy and Pharmacology, 51(2), 221–226. https://doi.org/10.1211/0022357991772178
  23. Koca Kutlu, A., Çeçen, D., Gürgen, S.G., Sayın, O., & Çetin, F. (2013). A Comparison Study of Growth Factor Expression Following Treatment with Transcutaneous Electrical Nerve Stimulation, Saline Solution, Povidone-Iodine, and Lavender Oil in Wounds Healing. Evidence-Based Complementary and Alternative Medicine, 2013, 1–9. https://doi.org/10.1155/2013/361832
  24. Kritsidima, M., Newton, T., & Asimakopoulou, K. (2010). The Effects of Lavender Scent On Dental Patient Anxiety Levels: A Cluster Randomised‐Controlled Trial. Community Dentistry and Oral Epidemiology, 38(1), 83–87. https://doi.org/10.1111/j.1600-0528.2009.00511.x
  25. Lee, B.H., Lee, J.S., & Kim, Y.C. (2016). Hair Growth-Promoting Effects of Lavender Oil in C57BL/6 Mice. Toxicological Research, 32(2), 103–108. https://doi.org/10.5487/TR.2016.32.2.103
  26. Lin, C.-W., Yu, C.-W., Wu, S.-C., & Yih, K.-H. (2009). DPPH free-Radical Scavenging Activity, Total Phenolic Contents and Chemical Composition Analysis of Forty-Two Kinds of Essential Oils. Journal of Food and Drug Analysis, 17(5), 386-395. https://doi.org/10.38212/2224-6614.2594
  27. Lis-Balchin, M., & Hart, S. (1999). Studies On The Mode of Action of The Essential Oil of Lavender Lavandula angustifolia P. Miller). Phytotherapy Research, 13(6), 540–542. https://doi.org/10.1002/(SICI)1099-1573(199909)13:6<540::AID-PTR523>3.0.CO;2-I
  28. Loutrari, H., Hatziapostolou, M., Skouridou, V., Papadimitriou, E., Roussos, C., Kolisis, F.N., & Papapetropoulos, A. (2004). Perillyl Alcohol Is an Angiogenesis Inhibitor. The Journal of Pharmacology and Experimental Therapeutics, 311(2), 568–575. https://doi.org/10.1124/jpet.104.070516
  29. Mayaud, L., Carricajo, A., Zhiri, A., & Aubert, G. (2008). Comparison of Bacteriostatic and Bactericidal Activity of 13 Essential Oils Against Strains With Varying Sensitivity To Antibiotics. Letters in Applied Microbiology 47(3), 167–173. https://doi.org/10.1111/j.1472-765X.2008.02406.x
  30. Miastkowska, M., Kantyka, T., Bielecka, E., Kałucka, U., Kamińska, M., Kucharska, M., Kilanowicz, A., Cudzik, D., & Cudzik, K. (2021). Enhanced Biological Activity of a Novel Preparation of Lavandula angustifolia Essential Oil. Molecules, 26(9), 2458-2479. https://doi.org/10.3390/molecules26092458
  31. Mori, H.-M., Kawanami, H., Kawahata, H., & Aoki, M. (2016). Wound Healing Potential of Lavender Oil By Acceleration of Granulation and Wound Contraction Through Induction of TGF-β In A Rat Model. BMC Complementary and Alternative Medicine, 16(144), 1-11. https://doi.org/10.1186/s12906-016-1128-7
  32. Moteki, H., Hibasami, H., Yamada, Y., Katsuzaki, H., Imai, K., & Komiya, T. (2002). Specific Induction of Apoptosis By 1,8-cineole In Two Human Leukemia Cell Lines, But Not A In Human Stomach Cancer Cell Line. Oncology Reports, 9(4), 757-760. https://doi.org/10.3892/or.9.4.757
  33. Mukherjee, P.K. (2015). Evidence-Based Validation of Herbal Medicine. Elsevier, Amsterdam.
  34. Porter, C.J.H., Pouton, C.W., Cuine, J.F., & Charman, W.N. (2008). Enhancing Intestinal Drug Solubilisation Using Lipid-Based Delivery Systems. Advanced Drug Delivery Reviews, 60(6), 673–691. https://doi.org/10.1016/j.addr.2007.10.014
  35. Rahayu, S.S., Kaewsaneha, C., Opaprakasit, P., Wongngam, Y., & Polpanich, D. (2024). Fabrication of Lavender Essential Oil-Loaded Polyurethane Nanoparticles Via A Facile Swelling-Diffusion Method As Hydrocolloid Agents For Wound Healing Applications. Emergent Materelias. https://doi.org/10.1007/s42247-024-00887-8
  36. Sanei-Dehkordi, A., Abdollahi, A., Montaseri, Z., Safari, M., Rostami Chaijan, M., & Osanloo, M. (2023). Lavender and Geranium Essential Oil-Loaded Nanogels with Promising Repellent and Antibacterial Effects. Psyche: A Journal of Entomology, 2023, 1–9. https://doi.org/10.1155/2023/9911066
  37. Sienkiewicz, M., Głowacka, A., Kowalczyk, E., Wiktorowska-Owczarek, A., Jóźwiak-Bębenista, M., & Łysakowska, M. (2014). The Biological Activities of Cinnamon, Geranium and Lavender Essential Oils. Molecules, 19(12), 20929–20940. https://doi.org/10.3390/molecules191220929
  38. Sofi, H.S., Akram, T., Tamboli, A.H., Majeed, A., Shabir, N., & Sheikh, F.A. (2019). Novel Lavender Oil and Silver Nanoparticles Simultaneously Loaded Onto Polyurethane Nanofibers For Wound-Healing Applications. International Journal of Pharmaceutics, 569(2019), 118590-118602. https://doi.org/10.1016/j.ijpharm.2019.118590
  39. Soković, M., Petar, D.M., Dejan, B., & van Griensven, L.J.L.D. (2007). Chemical Composition and Antibacterial Activity of Essential Oils of Ten Aromatic Plants against Human Pathogenic Bacteria. Food, Global Science Books, 1(1), 1-7.
  40. Stanojevic, L., Stankovic, M., Cakic, M., Nikolic, V., Nikolic, L., Ilic, D., & Radulovic, N. (2011). The Effect of Hydrodistillation Techniques On Yield, Kinetics, Composition And Antimicrobial Activity of essential Oils From Flowers of Lavandula officinalis L. Hemijska Industrija, 65(4), 455–463. https://doi.org/10.2298/HEMIND110129047S
  41. Styles, J.L. (1997). The Use of Aromatherapy In Hospitalized Children With HIV Disease. Complementary Therapies in Nursing and Midwifery, 3, 16–20. https://doi.org/10.1016/S1353-6117(97)80029-7
  42. Teranishi, R., Buttery, R.G., & Sugisawa, H. (Eds.). (1993). Bioactive Volatile Compounds from Plants, ACS Symposium Series. American Chemical Society, Washington, DC. https://doi.org/10.1021/bk-1993-0525
  43. Turek, C., & Stintzing, F.C. (2013). Stability of Essential Oils: A Review. 2 Comprehensive Reviews in Food Science and Food Safety, 12(1), 40–53. https://doi.org/10.1111/1541-4337.12006
  44. Vârban, D., Zăhan, M., Pop, C.R., Socaci, S., Ștefan, R., Crișan, I., Bota, L.E., Miclea, I., Muscă, A.S., Deac, A.M., & Vârban, R. (2022). Physicochemical Characterization and Prospecting Biological Activity of Some Authentic Transylvanian Essential Oils: Lavender, Sage and Basil. Metabolites, 12(10), 962-983. https://doi.org/10.3390/metabo12100962
  45. Viuda-Martos, M., Mohamady, M.A., Fernández-López, J., Abd ElRazik, K.A., Omer, E.A., Pérez-Alvarez, J.A., & Sendra, E. (2011). In Vitro Antioxidant and Antibacterial Activities of Essentials Oils Obtained From Egyptian Aromatic Plants. Food Control, 22(11), 1715–1722. https://doi.org/10.1016/j.foodcont.2011.04.003
  46. Wattenberg, L.W. (1991). Inhibition of Azoxymethane-Induced Neoplasia of The Large Bowel By 3-hydroxy-3,7,11-trimethyl-l,6,10-dodecatriene (nerolidol). Carcinogenesis, 12(1), 151–152. https://doi.org/10.1093/carcin/12.1.151
  47. Yamada, K., Mimaki, Y., & Sashida, Y. (1994). Anticonvulsive Effects of Inhaling Lavender Oil Vapour. Biological & Pharmaceutical Bulletin 17(2), 359–360. https://doi.org/10.1248/bpb.17.359
  48. Zhang, Z., Chen, H., Chan, K.K., Budd, T., & Ganapathi, R. (1999). Gas Chromatographic–Mass Spectrometric Analysis of Perillyl Alcohol and Metabolites In Plasma. Journal of Chromatography B: Biomedical Sciences and Applications, 728(1), 85–95. https://doi.org/10.1016/S0378-4347(99)00065-1