Main Article Content
Abstract
Background: Mangosteen peel (Garcinia mangostana L.) has been shown to stimulate the regeneration of damaged body cells and have an antimicrobial activity that can be beneficial in healing burns. Therefore, it is necessary to make it into a gel dosage form that has the advantages of being easily washed with water, high adhesion, cooling of the skin, and good drug release.
Objective: To determine the effect of varying concentrations of ethanol extract of mangosteen peel in a gel formulation on wound healing in burns and the physical properties of the gel.
Methods: Mangosteen peel extract was obtained by maceration method using ethanol 70%. This extract was formulated in a gel dosage form with variations of extract concentration, namely F I (5%), F II (10%), and F III (15%). The gels were then tested for their physical properties (organoleptic, homogeneity, pH, spreadability, adhesiveness, and physical stability) and their activity against burns experimentally using mice as test animals. Burns were made by using a hot plate with an area of 2 cm x 2 cm.
Results: The increase of extract concentration could increase spreadability (p>0.05), adhesiveness (p>0,05), and percentage of healing activity against burns as shown by a significant difference between FI and FIII. On the other hand, the difference in the concentration of the extract did not affect pH (all formulations have pH of 3.5); all formulas also remained homogenous and stable after centrifugation.
Conclusion: The best physical properties and wound healing activity for burns was shown by the gel with the ethanol extract of mangosteen peel at a concentration of 15%.
Objective: To determine the effect of varying concentrations of ethanol extract of mangosteen peel in a gel formulation on wound healing in burns and the physical properties of the gel.
Methods: Mangosteen peel extract was obtained by maceration method using ethanol 70%. This extract was formulated in a gel dosage form with variations of extract concentration, namely F I (5%), F II (10%), and F III (15%). The gels were then tested for their physical properties (organoleptic, homogeneity, pH, spreadability, adhesiveness, and physical stability) and their activity against burns experimentally using mice as test animals. Burns were made by using a hot plate with an area of 2 cm x 2 cm.
Results: The increase of extract concentration could increase spreadability (p>0.05), adhesiveness (p>0,05), and percentage of healing activity against burns as shown by a significant difference between FI and FIII. On the other hand, the difference in the concentration of the extract did not affect pH (all formulations have pH of 3.5); all formulas also remained homogenous and stable after centrifugation.
Conclusion: The best physical properties and wound healing activity for burns was shown by the gel with the ethanol extract of mangosteen peel at a concentration of 15%.
Keywords
Gel Burns Physical properties Mangosteen peel extract
Article Details
License
Authors who publish in the Jurnal Kedokteran dan Kesehatan Indonesia agree to the following terms:
- Authors retain copyright and grant Jurnal Kedokteran dan Kesehatan Indonesia right of first publication with the work simultaneously licensed under a Creative Commons Attribution Licence that allows others to adapt (remix, transform, and build) upon the work non-commercially with an acknowledgement of the work's authorship and initial publication in Jurnal Kedokteran dan Kesehatan Indonesia.
- Authors are permitted to share (copy and redistribute) the journal's published version of the work non-commercially (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in Jurnal Kedokteran dan Kesehatan Indonesia.
How to Cite
Sugihartini, N., & Wiradhika, R. Y. (2017). Gel formulation of ethanol extract of mangosteen peel (Garcinia mangostana L.) as a medication for burns in wistar rats. JKKI : Jurnal Kedokteran Dan Kesehatan Indonesia, 8(2), 110–117. https://doi.org/10.20885/JKKI.Vol8.Iss2.art6