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Submitted
September 5, 2020
Accepted
September 5, 2020
Published
September 5, 2020
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Abstract

Tujuan penelitian ini adalah melakukan biosintesis karakterisasi nanopartikel emas dari esktrak daun tin yang berkhasiat sebagai antikanker payudara khususnya terhadap sel T47D. Biosintesis dilakukan dengan cara mencampurkan ekstrak daun tin hasil maserasi dengan larutan HAuCl4 menggunakan ultrasonikasi. Terbentuknya nanopartikel emas ditunjukkan dengan terjadinya perubahan warna dari kuning menjadi merah muda pada jam ke-3, panjang gelombang 544,40 nm, ukuran partikel 80,46 ± 0,288 nm dengan nilai indeks polidispersi 0,292 ± 0,013 Ð. Morfologi sediaan menunjukkan bentuk segitiga, heksagonal, dan bulat. Hasil FTIR menunjukkan adanya gugus C=O dan –OH yang menandakan adanya flavonoid. Nanopartikel emas daun tin memiliki IC50 terhadap sel kanker payudara T47D dan sel vero berturut-turut sebesar 81,43 ppm dan 74,09 ppm. Dapat disimpulkan bahwa ekstrak daun tin dapat digunakan untuk pembuatan nanopartikel emas dengan sederhana dan ramah lingkungan serta memiliki potensi sebagai antikanker payudara namun tidak selektif terhadap sel vero.

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  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
Syukri, Y., Nugroho, B. H., Febriana, Y., Ningrum, A. D. K., & Maharani, G. A. (2020). INOVASI PENGOBATAN ANTIKANKER PAYUDARA DARI NANOPARTIKEL EMAS EKSTRAK DAUN TIN (Ficus carica L.). Khazanah: Jurnal Mahasiswa, 11(1). Retrieved from https://journal.uii.ac.id/khazanah/article/view/16661
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