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Oxidative stress resulting from the increased production of reactive oxygen species plays
a key role in the development of diabetes mellitus and its complications. Phaleria macrocarpa, a
traditional plant from Indonesia, has been used empirically to control cancer, arthritis, and diabetes
in society. The anti-diabetic effect and antioxidant activity of ethyl acetate (EtOAc) of Phaleria
macrocarpa (PM) was investigated in alloxan-induced diabetic rats. After two weeks administration
of PM, liver antioxidant enzyme and hyperglycemic state were evaluated. The result showed that
EtOAc fraction treatments reduced blood glucose levels in diabetic rats by oral administration
(P<0.05). Serum glutamic-oxaloacetic transaminase (sGOT) and serum glutamic-pyruvatetransaminase
(sGPT) also diminished by PM supplementation. The superoxide dismutase (SOD),
catalase (CAT), and glutathione-peroxidase (GPx) activities, and glutathione (GSH) level in the
alloxan-induced diabetic rats were decreased significantly (P<0.05) compared with those in the
normal rats but restored by EtOAc fraction treatments. The result of the present study concluded
that the diabetic effect of EtOAc fraction of PM against alloxan-induced diabetic rats is mediated
either by preventing the decline of hepatic antioxidant status or due to its indirect radical scavenging

Keywords: Ethyl acetate, Diabetic, Oxidative Stress, Phaleria macrocarpa

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