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Abstract
ABSTRACT
A research on acute toxicity of effervescent tablet from Piper betle leaf extractum on wistar
albino male rats was done. This research aimed to determine acute toxicity potential of
effervescent tablet from piper betle leaf extractum, evaluated clinical symptom that perhaps occur
due to the giving of effervescent tablet, single dosage orally on 24 hours to 15 days observation.
The research uses male rats, which are divided into 5 groups. Group I was negative control with
aquadest. Group II was given sample with 0,38 g/kgBW dosage. Then, succesively group III with
1,03 g/kgBW dosage, group IV with 2,79 g/kgBW dosage and group V was given test sample with
highest dosage, that was 7,50 g/kgBW dosage. On the basis of data analysis result having been
performed both quantitively and qualitatively, it could be said that in general, the giving of
effervescent tablet from Piper betle leaf extractum single dosage orally on male rats from 0,38
g/kgBW dosage to highest level (7,50 g/kgBW) or approximately 19,74 times of therapy dosage,
didn’t cause toxic effect. It didn’t cause mortality on research animal. So we can determine the
quasi LD50, that was bigger than 7,50 g/kgBW, according to Loomis criteria (1978), that acute
toxicity potential of effervescent tablet from piper betle extractum was practically not toxic category.
Key words: acute toxicity, effervescent tablet, Piper betle